16054-78-7

Upstream product

• 37077-81-9 1,2-isopropylidene-α-D-ribofuranose 
• 114861-14-2 1,2-O-isopropylidene-5-O-(t-butyldiphenylsilyl)-α-D-xylofuranose 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 18549-40-1 1,2-O-isopropylidene-α-D-glucofuranose 
• 75783-45-8 (3aR,5R,6aS)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxol-6-one 
• 190970-10-6 1,2-O-isopropylidene-5-O-tert-butyldiphenylsilyl-α-D-ribofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 100-39-0 benzyl bromide 
• 55735-86-9 3,5-O-dibenzyloxy-1,2-O-isorpopylidene-α-D-ribofuranose 
• 16054-77-6 (3R,4S,5R)-4-(benzyloxy)-5-(benzyloxymethyl)tetrahydrofuran-2,3-diol 

Downstream Products

• 138679-69-3 1,4-anhydro-3,5-di-O-benzyl-D-ribitol 
• 16054-79-8 2.4-Di-O-benzyl-1.3-di-O-p-nitrobenzyl-D-erythrit 
• 765942-31-2 (2R,3R,4S)-1-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2,4,5-tris-(tert-butyl-dimethyl-silanyloxy)-pentan-3-ol 
• 161452-62-6 (2R)-1,4-anhydro-3,5-di-O-benzyl-2-C-(2,6-diaminopurin-9-yl)-2-deoxy-D-arabitol 
• 161452-69-3 (2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2--D-arabitol 
• 161452-72-8 (2R)-1,4-anhydro-3,5-di-O-benzyl-2-C-(cytosin-1-yl)-2-deoxy-D-arabitol 
• 161452-71-7 (2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2-C-(uracil-1-yl)-D-arabitol 
• 161452-60-4 1,4-anhydro-3,5-di-O-benzyl-2-O-methanesulfonyl-D-ribitol 
• 161452-65-9 (2R)-1,4-anhydro-2-azido-3,5-di-O-benzyl-2-deoxy-D-arabitol 
• 161452-67-1 (2R)-2-amino-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-D-arabitol 
• 151825-72-8 (2R)-2-C-(adenin-9-yl)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-D-arabitol 
• 765942-29-8 (2S,3S,4R)-3,5-O-dibenzyloxy-1,2,4-O-tri-tert-butyldimethylsilyloxypentane 

Relevant academic research and scientific papers

Independent generation and characterization of a C2′-oxidized abasic site in chemically synthesized oligonucleotides

Abasic lesions, which are formed endogenously and as a consequence of exogenous agents, are lethal and mutagenic. Hydrogen atom abstraction from C2′ in DNA under aerobic conditions produces an oxidized abasic lesion (C2-AP), along with other forms of DNA

Nucleosides and nucleotides. 132. Synthesis and biological evaluations of ring-expanded oxetanocin analogues: Purine and pyrimidine analogues of 1,4-anhydro-2-deoxy-D-arabitol and 1,4-anhydro-2-deoxy-3-hydroxymethyl-D-arabitol

(2R)-2-C-(Adenin-9-yl)- 1,4-anhydro-2-deoxy-D-arabitol (2) and (2R, 3R)-2-C-(adenin-9-yl)- 1,4-anhydro- 2,3-dideoxy-3-C-hydroxymethyl-D-arabitol (3), and their 2,6-diaminopurine analogues 4 and 5 were synthesized from corresponding 1,4-anhydro-D-ribitol derivatives, which were readily obtained from D-glucose. The corresponding guanine isonucleosides 6 and 7 were obtained from 4 and 5 by enzymatic deamination with adenosine deaminase. Pyrimidine counterparts 8 and 9 were synthesized via construction of the pyrimidine moiety from amino derivatives of the 1,4-anhydro-D-arabitol derivatives. Antiviral activity of these ring-expanded derivatives of oxetanocins towards HSV-1, HSV-2, HCMV, and HBV in vitro was examined along with their cytotoxicity against L1210 and KB cells in vitro.