138679-69-3

Upstream product

• 16054-78-7 (2S,3S,4R)-3,5-O-dibenzyloxy-1,2,4-pentanetriol 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 18549-40-1 1,2-O-isopropylidene-α-D-glucofuranose 
• 55735-86-9 3,5-O-dibenzyloxy-1,2-O-isorpopylidene-α-D-ribofuranose 
• 37077-81-9 1,2-isopropylidene-α-D-ribofuranose 
• 161452-59-1 1,4-anhydro-3,5-di-O-benzyl-2-O-isopropyl-D-ribitol 
• 55775-39-8 1-O-methyl-3,5-di-O-benzyl-D-ribofuranoside 

Downstream Products

• 161452-60-4 1,4-anhydro-3,5-di-O-benzyl-2-O-methanesulfonyl-D-ribitol 
• 151825-71-7 Toluene-4-sulfonic acid (3S,4R,5R)-4-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-3-yl ester 
• 143191-83-7 1-[(3S,5S)-5-(hydroxymethyl)tetrahydrofuran-3-yl]thymine 
• 140623-93-4 1,4-anhydro-2-deoxy-2-<3,4-dihydro-2,4-dioxo-5-methyl-1(2H)-pyrimidinyl>-D-arabinitol 
• 161452-62-6 (2R)-1,4-anhydro-3,5-di-O-benzyl-2-C-(2,6-diaminopurin-9-yl)-2-deoxy-D-arabitol 
• 161452-69-3 (2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2--D-arabitol 
• 161452-72-8 (2R)-1,4-anhydro-3,5-di-O-benzyl-2-C-(cytosin-1-yl)-2-deoxy-D-arabitol 
• 161452-71-7 (2R)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-2-C-(uracil-1-yl)-D-arabitol 
• 161452-65-9 (2R)-1,4-anhydro-2-azido-3,5-di-O-benzyl-2-deoxy-D-arabitol 
• 161452-67-1 (2R)-2-amino-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-D-arabitol 
• 151825-72-8 (2R)-2-C-(adenin-9-yl)-1,4-anhydro-3,5-di-O-benzyl-2-deoxy-D-arabitol 

Relevant academic research and scientific papers

Nucleosides and nucleotides. 132. Synthesis and biological evaluations of ring-expanded oxetanocin analogues: Purine and pyrimidine analogues of 1,4-anhydro-2-deoxy-D-arabitol and 1,4-anhydro-2-deoxy-3-hydroxymethyl-D-arabitol

(2R)-2-C-(Adenin-9-yl)- 1,4-anhydro-2-deoxy-D-arabitol (2) and (2R, 3R)-2-C-(adenin-9-yl)- 1,4-anhydro- 2,3-dideoxy-3-C-hydroxymethyl-D-arabitol (3), and their 2,6-diaminopurine analogues 4 and 5 were synthesized from corresponding 1,4-anhydro-D-ribitol derivatives, which were readily obtained from D-glucose. The corresponding guanine isonucleosides 6 and 7 were obtained from 4 and 5 by enzymatic deamination with adenosine deaminase. Pyrimidine counterparts 8 and 9 were synthesized via construction of the pyrimidine moiety from amino derivatives of the 1,4-anhydro-D-arabitol derivatives. Antiviral activity of these ring-expanded derivatives of oxetanocins towards HSV-1, HSV-2, HCMV, and HBV in vitro was examined along with their cytotoxicity against L1210 and KB cells in vitro.