160723-51-3Relevant academic research and scientific papers
Generation of Acyl Radicals from 1-Oxidoalkylidenechromium(0) Complexes by Treatment with Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)copper(II) and Their Reactions with Olefins
Sakurai, Hidehiro,Narasaka, Koichi
, p. 2017 - 2020 (1994)
Tetramethylammonium pentacarbonyl(1-oxidoalkylidene)chromium(0) complexes are oxidized with bis(2,2,6,6-tetramethyl-3,5-heptanedionato)copper(II) to generate acyl radicals which react electron-deficient olefins, giving intermolecular addition products.
MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF
-
Paragraph 0492, (2021/01/23)
The disclosure relates to compounds and pharmaceutical compositions capable of modulating the hydroxysteroid 17-beta dehydrogenase (HSD17B) family member proteins including inhibiting the HSD17B member proteins, e.g. HSD17B13. The disclosure further relates to methods of treating liver diseases, disorders, or conditions with the compounds and pharmaceutical compositions disclosed herein, in which the HSD17B family member protein plays a role.
Metal-free reduction of unsaturated carbonyls, quinones, and pyridinium salts with tetrahydroxydiboron/water
Li, Tiejun,Peng, Henian,Tang, Wenjun,Tian, Duanshuai,Xu, Guangqing,Yang, He
, p. 4327 - 4337 (2021/05/31)
A series of unsaturated carbonyls, quinones, and pyridinium salts have been effectively reduced to the corresponding saturated carbonyls, dihydroxybenzenes, and hydropyridines in moderate to high yields with tetrahydroxydiboron/water as a mild, convenient, and metal-free reduction system. Deuterium-labeling experiments have revealed this protocol to be an exclusive transfer hydrogenation process from water. This journal is
Mg(OMe)2 promoted allylic isomerization of γ-hydroxy-α,β-alkenoic esters to synthesize γ-ketone esters
Lai, Luhao,Li, A-Ni,Zhou, Jiawei,Guo, Yarong,Lin, Li,Chen, Wei,Wang, Rui
, p. 2185 - 2190 (2017/03/17)
This work concerns the Mg(OMe)2 promoted allylic isomerization of γ-hydroxy-α,β-alkenoic esters with TMEDA as an additive. The isomerization proceeded under mild conditions and afforded γ-keto esters in high yield (up to 96%) within 2 h. Both (Z)- and (E)-γ-hydroxy-α,β-alkenoic esters were tolerated under the reaction conditions. This transformation involves the in situ formation of a dienolate intermediate from the easily accessible γ-hydroxy-α,β-alkenoic ester. The in situ generated dienolate can react with benzaldehyde and undergo a practical, useful tandem allylic isomerization-Aldol reaction to afford more functionalized compounds.
Benzoyl radicals from (hetero)aromatic aldehydes. Decatungstate photocatalyzed synthesis of substituted aromatic ketones
Ravelli, Davide,Zema, Michele,Mella, Mariella,Fagnoni, Maurizio,Albini, Angelo
experimental part, p. 4158 - 4164 (2010/11/02)
Benzoyl radicals are generated directly from (hetero)aromatic aldehydes upon tetrabutylammonium decatungstate ((n-Bu4N)4W 10O32), TBADT) photocatalysis under mild conditions. In the presence of α,β-unsaturated e
Biogenetic-type Synthesis of Sesquichamaenol
Paknikar, Shashikumar K.,Naik,Ramanamma
, p. 729 - 733 (2007/10/03)
A hypothetical biosynthetic pathway for the conversion of farnesylpyrophosphate into seaquichamaenol 1, a modified sesquiterpenoid isolated from Chaemaecyparis formosensis Matsum is proposed. The synthesis of 1 which lends experimental support to the prop
