84498-32-8Relevant academic research and scientific papers
Syntheses of Pyrroles, Pyridines, and Ketonitriles via Catalytic Carbopalladation of Dinitriles
Qi, Linjun,Li, Renhao,Yao, Xinrong,Zhen, Qianqian,Ye, Pengqing,Shao, Yinlin,Chen, Jiuxi
, p. 1097 - 1108 (2020/01/22)
The first example of the Pd-catalyzed addition of organoboron reagents to dinitriles, as an efficient means of preparing 2,5-diarylpyrroles and 2,6-diarylpyridines, has been discussed here. Furthermore, the highly selective carbopalladation of dinitriles with organoboron reagents to give long-chain ketonitriles has been developed as well. Based on the broad scope of substrates, excellent functional group tolerance, and use of commercially available substrates, the Pd-catalyzed addition reaction of arylboronic acid and dinitriles is expected to be significant in future synthetic procedures.
Facile Synthesis of γ-Ketonitriles in Water via C(sp2)–H Activation of Aromatic Aldehydes over Cu?g-C3N4 under Visible-Light
Bhardiya, Smita R.,Rai, Ankita,Rai, Vijai K.,Sheshma, Harendra,Singh, Manorama,Verma, Fooleswar
, p. 5841 - 5846 (2020/09/21)
A facile C(sp2)–H activation of aldehyde under visible-light conditions using Cu?g-C3N4 as photocatalyst and water as solvent is reported. The envisaged method involves photocatalytic intermolecular Stetter reaction using
Copper-Catalyzed Decarboxylative Oxyalkylation of Alkynyl Carboxylic Acids: Synthesis of ?-Diketones and ?-Ketonitriles
Li, Yi,Shang, Jia-Qi,Wang, Xiang-Xiang,Xia, Wen-Jin,Yang, Tao,Xin, Yangchun,Li, Ya-Min
supporting information, p. 2227 - 2230 (2019/03/26)
A novel copper-catalyzed decarboxylative oxyalkylation of alkynyl carboxylic acids with ketones and alkylnitriles via direct C(sp3)-H bond functionalization to construct new C-C bonds and C-O double bonds was developed. This transformation is featured by wide functional group compatibility and the use of readily available reagents, thus affording a general approach to ?-diketones and ?-ketonitriles. A possible mechanism is proposed.
Unactivated C(sp3)-H Bond Functionalization of Alkyl Nitriles with Vinylarenes and Mechanistic Studies
Lan, Xing-Wang,Wang, Nai-Xing,Bai, Cui-Bing,Lan, Cui-Lan,Zhang, Tong,Chen, Shi-Lu,Xing, Yalan
supporting information, p. 5986 - 5989 (2016/12/09)
The first example of a metal-free unactivated C(sp3)-H bond functionalization of alkyl nitriles with terminal vinylarenes to provide γ-ketonitrile derivatives is described. This protocol features simple operations, a broad substrate scope, and atom and step economy. In addition, Cu-catalyzed C(sp3)-H bond functionalization of azodiisobutyronitrile (AIBN) and analogues with terminal vinylarenes to generate γ-ketonitriles was also studied. A preliminary free-radical pathway was confirmed by capturing an alkyl radical, and a conjugate system was found that can stabilize radical intermediates and be in favor of this transformation. Density functional theory (DFT) calculations also provide important evidence of the free-radical pathway.
Biogenetic-type Synthesis of Sesquichamaenol
Paknikar, Shashikumar K.,Naik,Ramanamma
, p. 729 - 733 (2007/10/03)
A hypothetical biosynthetic pathway for the conversion of farnesylpyrophosphate into seaquichamaenol 1, a modified sesquiterpenoid isolated from Chaemaecyparis formosensis Matsum is proposed. The synthesis of 1 which lends experimental support to the prop
New Syntheses of 4-Isopropyl-4-m-tolyl-γ-butyrolactone and 2-Methyl-3-p-tolylcyclopent-2-enone
Ramanama, C. V.,Naik, C. G.,Paknikar, S. K.
, p. 761 - 762 (2007/10/02)
New routes for the synthesis of 4-isopropyl-4-m-tolyl-γ-butyrolactone (7) and 2-methyl-3-p-tolylcyclopent-2-enone (13) are reported.The compounds (7) and (13) are key intermediates in the synthesis of several aromatic sesquiterpenoids.
