1607465-89-3Relevant academic research and scientific papers
Synthesis and evaluation of ethyleneoxylated and allyloxylated chalcone derivatives for imaging of amyloid β plaques by SPECT
Fuchigami, Takeshi,Yamashita, Yuki,Haratake, Mamoru,Ono, Masahiro,Yoshida, Sakura,Nakayama, Morio
, p. 2622 - 2628 (2014/05/06)
We report radioiodinated chalcone derivatives as new SPECT imaging probes for amyloid β (Aβ) plaques. The monoethyleneoxy derivative 2 and allyloxy derivative 8 showed a high affinity for Aβ(1-42) aggregates with Ki values of 24 and 4.5 nM, res
