92855-02-2

Upstream product

• 13329-40-3 4-Iodoacetophenone 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1021493-94-6 1-(4-iodophenyl)-3-(4-methoxyphenyl)-4-nitrobutan-1-one 
• 1028801-20-8 4'-iodo-4-methoxy-chalcone oxime 
• 1350753-42-2 {4-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]phenyl}-3-(methoxyphenyl)prop-2-en-1-one 
• 1350753-41-1 {4-[(E)-2-(4-Hydroxy-3,5-dimethoxyphenyl)ethenyl]phenyl}-3-(4methoxyphenyl)-prop-2-en-1-one 
• 1607465-89-3 (E)-3-(4-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)phenyl)-1-(4-iodophenyl)prop-2-en-1-one 
• 1607465-88-2 (E)-3-(4-(2-(2-hydroxyethoxy)ethoxy)phenyl)-1-(4-iodophenyl)prop-2-en-1-one 
• 1607465-87-1 (E)-3-(4-(2-hydroxyethoxy)phenyl)-1-(4-iodophenyl)prop-2-en-1-one 
• 1607465-90-6 (E)-3-(4-(2-hydroxyethoxy)phenyl)-1-(4-tributylstannylphenyl)prop-2-en-1-one 
• 93315-04-9 3-<4-Iod-benzoyl>-2-<4-methoxy-phenyl>-propionsaeure 
• 93323-11-6 3-<4-Iod-benzoyl>-2-<4-methoxy-phenyl>-propionitril 

Relevant academic research and scientific papers

NARROW ABSORPTION POLYMER NANOPARTICLES AND RELATED METHODS

Polymers, monomers, narrow-band absorbing polymers, narrow-band absorbing monomers, absorbing units, polymer dots, and related methods are provided. Bright, luminescent polymer nanoparticles with narrow-band absorptions are provided. Methods for synthesizing absorbing monomers, methods for synthesizing the polymers, preparation methods for forming the polymer nanoparticles, and applications for using the polymer nanoparticles are also provided.

Synthesis and evaluation of ethyleneoxylated and allyloxylated chalcone derivatives for imaging of amyloid β plaques by SPECT

We report radioiodinated chalcone derivatives as new SPECT imaging probes for amyloid β (Aβ) plaques. The monoethyleneoxy derivative 2 and allyloxy derivative 8 showed a high affinity for Aβ(1-42) aggregates with Ki values of 24 and 4.5 nM, res

Solvent-free synthesis, spectral correlations and antimicrobial activities of some aryl e 2-propen-1-ones

Totally 38 aryl E 2-propen-1-ones including nine substituted styryl 4-iodophenyl ketones have been synthesised using solvent-free SiO 2-H3PO4 catalyzed Aldol condensation between respective methyl ketones and substituted benzaldehydes under microwave irradiation. The yields of the ketones are more than 80%. The synthesised chalcones were characterized by their analytical, physical and spectroscopic data. The spectral frequencies of synthesised substituted styryl 4-iodophenyl ketones have been correlated with Hammett substituent constants, F and R parameters using single and multi-linear regression analysis. The antimicrobial activities of 4-iodophenyl chalcones have been studied using Bauer-Kirby method.

COMPOSITION FOR TREATING DIABETES AND METABOLIC DISEASES AND A PREPARATION METHOD THEREOF

Disclosed is a chalcone composition for treating diabetes and metabolic syndromes. In particular, the chalcone compound bound with 2-halogen in ring A significantly decreases the blood glucose level in the in vitro anti-diabetic effect experiment. In the in vivo animal model, the leading chalcone compound can prevent the progression of diabetes and control the blood glucose level, and there is no significant difference in the gains in body weight. Throughout the seven-week administration, there are no hepatic or renal toxicity observed.

Stilbene-chalcone hybrids: Design, synthesis, and evaluation as a new class of antimalarial scaffolds that trigger cell death through stage specific apoptosis

Novel stilbene-chalcone (S-C) hybrids were synthesized via a sequential Claisen-Schmidt-Knoevenagel-Heck approach and evaluated for antiplasmodial activity in in vitro red cell culture using SYBR Green I assay. The most potent hybrid (11) showed IC50

A simple, modular synthesis of substituted pyridines

A simple, modular method to prepare highly substituted pyridines is disclosed. The method employs a cascade reaction comprising (1) a novel N-iminative, Cu-catalyzed cross-coupling of alkenylboronic acids at the N-O bond of α,β-unsaturated ketoxime O-pentafluorobenzoates, (2) electrocyclization of the resulting 3-azatriene, and (3) air oxidation affording highly substituted pyridines in moderate to excellent isolated yields (43-91%). Starting materials are readily available, and functional group tolerance is very good. Copyright

Functionalized BF2 chelated azadipyrromethene dyes

Fluorescent molecules that emit in the near infrared are potentially useful as probes for biotechnology. A relatively under-explored design for probes of this type are the aza-BODIPY dyes; this study was performed to enhance our understanding of these materials and ways in which they may be used in dye cassette systems. Thus, the aza-BODIPY dyes 1a-g were prepared. An advanced intermediate toward an eighth compound in the series, 6h, was made but it could not be complexed with boron effectively to give 1h. Spectroscopic properties of these compounds were recorded, and correlations between substituent effects, UV absorbance, fluorescence emissions, and quantum yields were made. Compound 1a was coupled with a fluorescein-alkyne derivative to give the energy transfer cassettes 2 and 3. Both these compounds gave poor energy transfer and the possible reasons for this were discussed.

Novel chalcones as probes for in vivo imaging of β-amyloid plaques in Alzheimer's brains

A novel series of chalcone derivatives for in vivo imaging β-amyloid plaques in the brain of Alzheimer's disease (AD) were synthesized and characterized. When in vitro binding studies using Aβ aggregates were carried out with chalcone derivatives, the bin