1607854-52-3Relevant academic research and scientific papers
Unusual ether-type resin glycoside dimers from the seeds of Cuscuta chinensis
Fan, Bo-Yi,Luo, Jian-Guang,Gu, Yu-Cheng,Kong, Ling-Yi
, p. 2003 - 2014 (2014)
Two new resin glycosides, cuses 3 (1) and 4 (2), were initially obtained from the seeds of Cuscuta chinensis. Both of them contained a reducing glucose unit, and thus existed as a pair of isomers. In order to solve the existing problem of tautomerism, the remanent resin glycoside fraction was converted into aminoalditol derivatives with p-anisidine, and then another eight new resin glycosides cuses 5-12 (3-10) were further isolated. Cuses 7-12 (6-10) were considered to be generated via glycosidation of two acylated oligosaccharides, and thus characterized as ether-type resin glycoside dimers. Their structures including absolute stereochemistry were elucidated by a combination of spectroscopic and chemical methods. Compounds 3-10 exhibited cytotoxic activity toward MCF-7, SMMC-7721, and MG-63 cell lines with IC50 values ranging from 8.72 to 59.35 μg/mL.
