160848-04-4Relevant articles and documents
New Route to Pyroglutamates via α-Chloro Amide Radical Cyclisation
Goodall, Karen,Parsons, Andrew F.
, p. 3257 - 3260 (2007/10/02)
The tributyltin hydride mediated radical cyclisation of N-(α-chloroacetamido)dehydroalanine derivatives prepared from serine proceeds regioselectively to give pyroglutamates in 47-74percent yield-the cyclisation of the intermediate carbamoylmethyl radical proceeds in a 'disfavoured' 5-endo-trig-manner.