160848-07-7

Basic information

• Product Name: methyl 2-(N-benzyl-2-chloroethanamido)propenoate
• Synonyms: methyl 2-(N-benzyl-2-chloroethanamido)propenoate
• CAS NO: 160848-07-7
• Molecular Weight: 267.712
• Mol File: 160848-07-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 2-(N-benzyl-2-chloroethanamido)propenoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(N-benzyl-2-chloroethanamido)propenoate(160848-07-7)
• EPA Substance Registry System: methyl 2-(N-benzyl-2-chloroethanamido)propenoate(160848-07-7)

Safety Data

• Hazardous Substances Data: 160848-07-7(Hazardous Substances Data)

Upstream product

• 160848-03-3 methyl (2R,S)-2-(N-benzylamino)-3-(tert-butyldimethylsiloxy)propanoate 
• 160848-04-4 2-[Benzyl-(2-chloro-acetyl)-amino]-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester 
• 79-04-9 chloroacetyl chloride 
• 144001-42-3 methyl 2-(benzylamino)-3-hydroxypropanoate 

Downstream Products

• 103301-78-6 1-benzyl-5-oxo-pyrrolidine-2-carboxylic acid methyl ester 
• 178100-15-7 2-[Benzyl-(2-iodo-acetyl)-amino]-acrylic acid methyl ester 

Relevant articles and documents

The Synthesis of α,β-Dehydroamino Acid Esters From Hydroxyamino Esters Using Haloacetyl Halides

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New Route to Pyroglutamates via α-Chloro Amide Radical Cyclisation

The tributyltin hydride mediated radical cyclisation of N-(α-chloroacetamido)dehydroalanine derivatives prepared from serine proceeds regioselectively to give pyroglutamates in 47-74percent yield-the cyclisation of the intermediate carbamoylmethyl radical proceeds in a 'disfavoured' 5-endo-trig-manner.