1612157-12-6

Basic information

• Product Name: C₁₆H₁₇N₃
• Synonyms: C₁₆H₁₇N₃
• CAS NO: 1612157-12-6
• Molecular Weight: 251.331
• Mol File: 1612157-12-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₇N₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₇N₃(1612157-12-6)
• EPA Substance Registry System: C₁₆H₁₇N₃(1612157-12-6)

Safety Data

• Hazardous Substances Data: 1612157-12-6(Hazardous Substances Data)

Upstream product

• 1632-83-3 1-Methylbenzimidazole 
• 15799-79-8 3-methoxy-N,N-dimethylaniline 
• 16088-19-0 norneostigmine 
• 6848-13-1 3-chloro-N,N-dimethylaniline 

Relevant articles and documents

Nickel-Catalyzed Heteroarenes Cross Coupling via Tandem C-H/C-O Activation

Inert aryl methyl ethers as coupling components via C-O activation have been established with a Ni catalyst for C-H activation of heteroarene. The key to simultaneous C-H/C-O bond activation is the use of sterically demanding o-tolylMgBr. The protocol is effective for a wide scope of substrates including naphthyl methyl ethers, anisoles, and a variety of other heteroarene derivatives. Detailed mechanistic studies indicated that the C-O cleavage is assisted via synergistic effect of nickel and Grignard reagent in this C-H/C-O reaction, which is supported by DFT calculation. At this stage, single-electron transfer can be ruled out as a main operative process for this tandem strategy.

N -heterocyclic carbene-palladium(II)-1-methylimidazole complex-catalyzed direct C-H bond arylation of (Benz)imidazoles with aryl chlorides

(Benz)imidazoles can be efficiently functionalized by (hetero)aryl chlorides via direct C-H bond arylation in the presence of a well-defined NHC-Pd(II)-Im complex. Under the optimal conditions, various activated, unactivated, and deactivated (hetero)aryl chlorides were successfully applied as the arylating reagents to achieve the 2-(hetero)aryl (benz)imidazoles in acceptable to high yields, giving a facile and alternative methodology for the direct C-H bond arylation of (benz)imidazoles.