160938-85-2Relevant articles and documents
Furan based cyclic oligopeptides selectively target G-quadruplex
Chakraborty, Tushar Kanti,Arora, Amit,Roy, Saumya,Kumar, Niti,Maiti, Souvik
, p. 5539 - 5542 (2007)
We report the binding properties of 18- and 24-membered cyclic oligopeptides developed from a novel furan amino acid, 5-(aminomethyl)-2- furancarboxylic acid, to G-quadruplex. Comparative analysis of the binding data of these ligands with G-quadruplex and
Furfurylamines from biomass: Transaminase catalysed upgrading of furfurals
Dunbabin, Alice,Subrizi, Fabiana,Ward, John M.,Sheppard, Tom D.,Hailes, Helen C.
, p. 397 - 404 (2017/01/29)
Furfural is recognised as an attractive platform molecule for the production of solvents, plastics, resins and fuel additives. Furfurylamines have many applications as monomers in biopolymer synthesis and for the preparation of pharmacologically active compounds, although preparation via traditional synthetic routes is not straightforward due to by-product formation and sensitivity of the furan ring to reductive conditions. In this work transaminases (TAms) have been investigated as a mild sustainable method for the amination of furfural and derivatives to access furfurylamines. Preliminary screening with a recently reported colorimetric assay highlighted that a range of furfurals were readily accepted by several transaminases and the use of different amine donors was then investigated. Multistep synthetic routes were required to synthesise furfurylamine derivatives for use as analytical standards, highlighting the benefits of using a one step biocatalytic route. To demonstrate the potential of using TAms for the production of furfurals, the amination of selected compounds was then investigated on a preparative scale.
Novel peptides comprising furanoid sugar amino acids for the treatment of cancer
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, (2010/02/10)
Anticancer peptides which incorporate furanoid sugar amino acids and compositions made using these peptides are described. Methods for synthesis of the peptides and for preparing the furanoid sugar amino acids are disclosed. The peptides and compositions made using the peptides have pharmacological applications of these peptides especially in the treatment and prevention of cancer and tumors.
