160938-85-2

Upstream product

• 6338-41-6 5-hydroxymethyl-furan-2-carboxylic acid 
• 13529-17-4 5-Formyl-2-furancarboxylic acid 
• 934-65-6 5-(aminomethyl)furan-2-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 83608-90-6 methyl 5-(azidomethyl)furan-2-carboxylate 
• 73751-06-1 methyl 2-(aminomethyl)-5-furanoate 
• 39238-09-0 5-chloromethyl-2-furancarboxylic acid 
• 2144-37-8 methyl 5-(chloromethyl)-2-furoate 
• 57-48-7 D-Fructose 
• 1623-88-7 5-chloromethylfurfural 
• 432550-39-5 5-(tert-butoxycarbonylamino-methyl)-furan-2-carboxylic acid methyl ester 

Downstream Products

• 51521-95-0 5-aminomethyl-2-furancarboxylic acid hydrochloride salt 

Relevant academic research and scientific papers

Furan based cyclic oligopeptides selectively target G-quadruplex

We report the binding properties of 18- and 24-membered cyclic oligopeptides developed from a novel furan amino acid, 5-(aminomethyl)-2- furancarboxylic acid, to G-quadruplex. Comparative analysis of the binding data of these ligands with G-quadruplex and

Cyclic trimer of 5-(aminomethyl)-2-furancarboxylic acid as a novel synthetic receptor for carboxylate recognition

A novel 18-membered cyclic oligopeptide 1 based on 5-(aminomethyl)-2-furancarboxylic acid (2), is developed as an excellent receptor for carboxylate binding having an association constant of 8.64×103 M-1 for tetrabutylammonium acetate in CD3CN. The synthesis of 1 was achieved by a high-yielding cyclotrimerization reaction of the unfunctionalized furan amino acid 2.

Furfurylamines from biomass: Transaminase catalysed upgrading of furfurals

Furfural is recognised as an attractive platform molecule for the production of solvents, plastics, resins and fuel additives. Furfurylamines have many applications as monomers in biopolymer synthesis and for the preparation of pharmacologically active compounds, although preparation via traditional synthetic routes is not straightforward due to by-product formation and sensitivity of the furan ring to reductive conditions. In this work transaminases (TAms) have been investigated as a mild sustainable method for the amination of furfural and derivatives to access furfurylamines. Preliminary screening with a recently reported colorimetric assay highlighted that a range of furfurals were readily accepted by several transaminases and the use of different amine donors was then investigated. Multistep synthetic routes were required to synthesise furfurylamine derivatives for use as analytical standards, highlighting the benefits of using a one step biocatalytic route. To demonstrate the potential of using TAms for the production of furfurals, the amination of selected compounds was then investigated on a preparative scale.

THIAZOLOPYRIMIDINE DERIVATIVE

The present invention provides a compound represented by the following Formula: wherein A is an aryl group or a heteroaryl group, each of which may be substituted; R 1 is a group which is bonded through carbon; R 2 is hydrogen or an aliphatic hydrocarbon group; and X is -NR 3 -, -O-, -S-, -SO-, -SO 2 -, or -CHR 3 -(wherein R 3 is hydrogen or an aliphatic hydrocarbon group), or a salt thereof, or a prodrug thereof, which has growth factor receptor tyrosine kinase inhibitory activity and low toxicity, and is useful for prevention and treatment of cancer, and thus can be sufficiently used as a medicine.

Novel peptides comprising furanoid sugar amino acids for the treatment of cancer

Anticancer peptides which incorporate furanoid sugar amino acids and compositions made using these peptides are described. Methods for synthesis of the peptides and for preparing the furanoid sugar amino acids are disclosed. The peptides and compositions made using the peptides have pharmacological applications of these peptides especially in the treatment and prevention of cancer and tumors.