934-65-6

Basic information

• Product Name: 5-(Aminomethyl)-2-furoic acid
• Synonyms: Ec-000.1532;5-Aminomethylfuroic acid;5-(aminomethyl)-2-furoic acid hydrochloride;MFCD20731136;5-(aminomethyl)-2-Furancarboxylic acid
• CAS NO: 934-65-6
• Molecular Formula: C₆H₇NO₃
• Molecular Weight: 141.13
• Mol File: 934-65-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 317.7°Cat760mmHg
• Flash Point: 146°C
• Appearance: /
• Density: 1.347g/cm³
• Vapor Pressure: 0.000158mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 5-(Aminomethyl)-2-furoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Aminomethyl)-2-furoic acid(934-65-6)
• EPA Substance Registry System: 5-(Aminomethyl)-2-furoic acid(934-65-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 934-65-6(Hazardous Substances Data)

Usage

General Description

5-(Aminomethyl)-2-furoic acid is a chemical compound that has a furan ring with an aminomethyl group attached to the 5-position. It is a derivative of furan and is a heterocyclic compound. This chemical is commonly used in the synthesis of pharmaceuticals and is also of interest in medicinal chemistry due to its potential biological activities. It has been studied for its potential as an anti-tumor agent and as a treatment for inflammatory diseases. Additionally, it has been investigated for its role in preventing neurodegenerative diseases and as an inhibitor of quorum sensing in bacteria.

InChI:InChI=1/C6H7NO3/c7-3-4-1-2-5(10-4)6(8)9/h1-2H,3,7H2,(H,8,9)

Upstream product

• 345991-81-3 5-[(chloroacetyl-amino)-methyl]-furan-2-carboxylic acid methyl ester 
• 5445-00-1 5-[(chloroacetyl-amino)-methyl]-furan-2-carboxylic acid ethyl ester 
• 1623-88-7 5-chloromethylfurfural 
• 39238-09-0 5-chloromethyl-2-furancarboxylic acid 
• 6338-41-6 5-hydroxymethyl-furan-2-carboxylic acid 
• 13529-17-4 5-Formyl-2-furancarboxylic acid 
• 614-99-3 Ethyl 2-furoate 
• 611-13-2 2-furoic acid methyl ester 

Downstream Products

• 840540-60-5 C₆H₁₁NO₃ 
• 60-32-2 6-aminohexanoic acid 
• 105-60-2 caprolactam 
• 160938-85-2 N-(Boc)-5-aminomethyl-2-furoic acid 
• 51521-95-0 5-aminomethyl-2-furancarboxylic acid hydrochloride salt 

Relevant articles and documents

Hybrid Conversion of 5-Hydroxymethylfurfural to 5-Aminomethyl-2-furancarboxylic acid: Toward New Bio-sourced Polymers

Hybrid catalysis, which combines chemo- and biocatalytic benefits, is an efficient way to address green chemistry principles. 5-Hydroxymethylfurfural (HMF) is a versatile building block in numerous industrial applications. To date, few studies have described the production of its amine derivatives and their polymers. Finding a good methodology to directly transform HMF to 5-aminomethyl-2-furancarboxylic acid (AMFC) therefore represents an important challenge. After selecting the best oxidation catalyst for HMF conversion to 5-aldehyde-2-furancarboxylic acid and immobilizing a transaminase onto a solid carrier, we implemented the first one-pot/two-steps hybrid catalytic process to produce AMFC (77 % yield); this is the most efficient AMFC catalytic production method from HMF reported to date. This process also produced 2,5-furandicarboxylic acid (21 % yield) as a major secondary product that can be applied to polymer syntheses such as polyethylene furanoate. Herein, we report a novel way to access new biosourced polymers based on HMF oxidized and aminated derivatives.

METHODS OF PRODUCING COMPOUNDS FROM 5-(HALOMETHYL)FURFURAL

Provided herein are methods of producing compounds, such as cyclohexanone, hexanediamine, hexanediol, hexamethylenediamine, caprolactam and nylon, from 5-(halomethyl)furfural.