1609485-04-2

Upstream product

• 885069-14-7 N-[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzothiazol-2-yl]acetamide 
• 1404227-84-4 5-bromo-2-methoxy-3-(4-fluorophenylsulfonamino)benzamide 
• 15864-32-1 2-amino-6-bromobenzothiazole 
• 16628-26-5 N-(6-bromo-1,3-benzothiazol-2-yl)acetamide 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 1579281-54-1 5-bromo-2-methoxy-3-nitrobenzamide 

Relevant academic research and scientific papers

2-methoxy-3-substituted sulfonyl amino-5 - (2-acetamido-6-benzothiazolyl) benzoyl amide compounds and its preparation and use

The invention discloses a 2-methoxyl-3-substituted sulfonamido-5-(2-acetamido-6-benzothiazolyl) benzamide compound, a preparation method and application thereof. The compound is characterized in that the structural formula of the compound is shown in a formula in the specification, wherein R is alkyl or aryl. The compound has remarkable in-vitro and in-vivo anti-tumor activities and is applicable to preparation of anti-tumor medicinal preparations.

Combination of 2-methoxy-3-phenylsulfonylaminobenzamide and 2-aminobenzothiazole to discover novel anticancer agents

The fragment of 2-substituted-3-sulfonylaminobenzamide has been proposed to replace the fragment of 2-substituted-3-sulfonylaminopyridine in PI3K and mTOR dual inhibitors to design novel anticancer agents based on bioisostere. The combination of the fragm