1609487-65-1

Basic information

• Product Name: N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide
• Synonyms: N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide
• CAS NO: 1609487-65-1
• Molecular Weight: 353.728
• Mol File: 1609487-65-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide(1609487-65-1)
• EPA Substance Registry System: N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide(1609487-65-1)

Safety Data

• Hazardous Substances Data: 1609487-65-1(Hazardous Substances Data)

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 
• 69559-40-6 N-(2-benzoyl-4-chlorophenyl)-2,2,2-trifluoroacetamide 
• 4301-14-8 acetylenemagnesium bromide 

Downstream Products

• 1609487-62-8 2-(5-chloro-3-phenyl-1H-indol-2-yl)-N-(2,4,4-trimethylpentan-2-yl)acetamide 
• 1609487-49-1 N-tert-butyl-2-(5-chloro-3-phenyl-1H-indol-2-yl)acetamide 

Relevant articles and documents

Palladium-catalyzed tandem intramolecular oxy/amino-palladation/isocyanide insertion: Synthesis of α-benzofuranyl/indolylacetamides

A novel palladium-catalyzed approach to 2-benzofuranyl/indolylacetamides from 1-(o-hydroxy/aminophenyl)propargylic alcohols and isocyanides is described. The reaction proceeds through a cascade that includes oxy/aminopalladation, isocyanide insertion, and 1,4-hydroxyl migration. No oxidant or ligand is needed to promote the cascade, and the reactions are carried out under mild conditions to afford the products through high functional tolerance.