160952-53-4

Upstream product

• 165529-01-1 2-[1-{5-tert-Butoxycarbonyl-2-[(tert-butoxycarbonyl-phenethyl-amino)-methyl]-phenyl}-meth-(Z)-ylidene]-succinic acid dimethyl ester 
• 165529-02-2 methyl 3-methoxycarbonyl-4-[5-(t-butoxycarbonyl)-2-[[[N-(2-phenylethyl)-N-t-butoxycarbonyl]amino]methyl]-phenyl]butanoate 
• 165529-03-3 methyl 3-methoxycarbonyl-4-[5-carboxy-2-[[N-(2-phenylethyl)amino]methyl]phenyl]butanoate 
• 160952-52-3 (+/-)-7-carboxy-3-oxo-2-(2-phenylethyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate 
• 160952-48-7 t-butyl 3-bromo-4-[[[N-(2-phenylethyl)-N-t-butoxycarbonyl]amino]methyl]benzoate 
• 160952-47-6 t-butyl 3-bromo-4-[[(2-phenylethyl)amino]methyl]-benzoate 
• 165528-99-4 3-bromo-4-bromomethyl-benzoic acid tert-butyl ester 
• 160952-57-8 3-bromo-4-methylbenzoic acid tert-butyl ester 
• 64-04-0 phenethylamine 
• 7697-26-9 3-bromo-4-methylbenzoic acid 

Downstream Products

• 171049-49-3 methyl (R,S)-7-[[[4-(aminoiminomethyl)phenyl]methylamino]-carbonyl]-2,3,4,5-tetrahydro-3-oxo-2-(2-phenylethyl)-1H-2-benzazepine-4-acetate 

Relevant academic research and scientific papers

Bicyclic fibrinogen antagonists

PCT No. PCT/US95/00248 Sec. 371 Date Jul. 3, 1996 Sec. 102(e) Date Jul. 3, 1996 PCT Filed Jan. 9, 1995 PCT Pub. No. WO96/18619 PCT Pub. Date Jul. 13, 1995Certain compounds within formula (I) are inhibitors of platelet aggregation: wherein A1 is NH or CH2;

Synthesis of a 2-benzazepine analog of a potent, nonpeptide GPIIb/IIIa antagonist

The preparation of the 2-benzazepine derivative 3 as an analog of the potent, nonpeplide GPIIb/IIIa antagonist 2 is reported. The synthetic route employs as key steps a Heck arylation of dimethyl itaconate and a selective cyclization to form the aryl-fuse