1609939-34-5

Basic information

• Product Name: 2-methoxy-3-phenylisoquinolin-1(2H)-one
• Synonyms: 2-methoxy-3-phenylisoquinolin-1(2H)-one
• CAS NO: 1609939-34-5
• Molecular Weight: 251.285
• Mol File: 1609939-34-5.mol

Chemical Properties

• CAS DataBase Reference: 2-methoxy-3-phenylisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-3-phenylisoquinolin-1(2H)-one(1609939-34-5)
• EPA Substance Registry System: 2-methoxy-3-phenylisoquinolin-1(2H)-one(1609939-34-5)

Safety Data

• Hazardous Substances Data: 1609939-34-5(Hazardous Substances Data)

Upstream product

• 2446-51-7 N-methoxybenzamide 
• 70-11-1 α-bromoacetophenone 
• 532-27-4 1-chloroacetophenone 
• 7257-94-5 1-phenyl-2-(p-tolylsulfonyloxy)ethanone 
• 20187-61-5 mesyloxyacetophenone 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 1225463-02-4 2-iodo-N-methoxybenzamide 
• 609-67-6 2-Iodobenzoyl chloride 

Downstream Products

• 7115-13-1 3-phenyl-2H-isoquinolin-1-one 

Relevant articles and documents

Access to divergent benzo-heterocycles: Via a catalyst-dependent strategy in the controllable cyclization of o -alkynyl- N -methoxyl-benzamides

A chemo- and regio-selectively controllable approach for construction of diverse benzo-heterocycles is established. A new strategy for using the ligand effect in gold catalysis to control the regioselectivity in the cyclization of o-alkynyl-N-methoxyl-benzamide is successfully achieved. Meanwhile, the chemoselectivity between nitrogen and oxygen nucleophiles is precisely switched by gold and platinum catalysts.

Tunable Synthesis of 3-Hydroxylisoquinolin-1,4-dione and Isoquinolin-1-one Enabled by Copper-Catalyzed Radical 6- endo Aza-cyclization of 2-Alkynylbenzamide

In this work, switchable synthesis of isoquinolin-1-one and 3-hydroxylisoquinolin-1,4-dione from 2-alkynylbenzamide is reported. The transformation works well with good yields and a broad reaction scope. The synthetic switch for providing isoquinolin-1-one and 3-hydroxylisoquinolin-1,4-dione is enabled by the use of a N2 or O2 atmosphere. Mechanism studies show that the reaction proceeds in a regioselective manner via a N-center radical 6-endo-dig aza-cyclization pathway.

Rhodium(III)-catalyzed chemodivergent annulations between: N-methoxybenzamides and sulfoxonium ylides via C-H activation

Chemodivergent and redox-neutral annulations between N-methoxybenzamides and sulfoxonium ylides have been realized via Rh(iii)-catalyzed C-H activation. The sulfoxonium ylide acts as a carbene precursor, and coupling occurs under acid-controlled condition

α-MsO/TsO/Cl ketones as oxidized alkyne equivalents: Redox-neutral rhodium(III)-catalyzed C-H activation for the synthesis of N-heterocycles

α-Halo and pseudohalo ketones are used for the first time as C(sp3)-based electrophiles in transition-metal-catalyzed C-H activation and as oxidized alkyne equivalents in RhIII-catalyzed redox-neutral annulations to generate diverse N-heterocycles. This transformation is efficient and scalable. Due to the mild reaction conditions, a variety of functional groups could be tolerated. Who needs alkynes? α-Halo and pseudohalo ketones (as C(sp3)-based electrophiles) are utilized as oxidized alkyne equivalents in RhIII-catalyzed redox-neutral annulations to efficiently generate diverse N-heterocycles. Owing to the mild reaction conditions, a variety of functional groups are tolerated.