1610-33-9

Usage

Uses

Used in Pharmaceutical Industry:
Phosphonic acid, ethyl methyl ester is used as a precursor for the synthesis of various pharmaceutical compounds, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
Phosphonic acid, ethyl methyl ester is utilized as a precursor in the production of agrochemicals, playing a role in the creation of pesticides, herbicides, and other agricultural products to enhance crop protection and yield.
Used as a Stabilizer:
Phosphonic acid, ethyl methyl ester is employed as a stabilizer in different industrial processes, helping to maintain the stability and quality of products during manufacturing and storage.
Used as a Chelating Agent:
It serves as a chelating agent, which is crucial for binding and sequestering metal ions in various applications, thus preventing unwanted chemical reactions and promoting process efficiency.
Safety and Handling:
Given its flammable nature, Phosphonic acid, ethyl methyl ester requires careful handling and the use of appropriate protective equipment. Moreover, adhering to proper storage and disposal procedures is essential to minimize environmental impact.

InChI:InChI=1/C3H9O3P/c1-3-7(4,5)6-2/h3H2,1-2H3,(H,4,5)/p-1

Upstream product

• 20502-40-3 ethyl dimethyl phosphite 
• 67-56-1 methanol 
• 64-17-5 ethanol 
• 6919-81-9 2,4-diethoxy-1,3-diphenyl-cyclodiphosphazane 
• 762-04-9 phosphonic acid diethyl ester 
• 109-73-9 N-butylamine 
• 74-88-4 methyl iodide 
• 697-31-4 1-ethoxy-3-methyl-2,5-dihydro-1H-phosphole 1-oxide 
• 1005-95-4 1-ethoxy-3,4-dimethyl-Δ³-phospholen oxide 
• 5927-18-4 trimethyl phosphonoacetate 
• 64227-37-8 6-(4-methoxybenzylidene)-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one 
• 15845-66-6 Ethylphosphorige Saeure 
• 1498-42-6 phosphorodichloridous acid ethyl ester 

Downstream Products

• 762-04-9 phosphonic acid diethyl ester 
• 597557-92-1 Ethyl α-Benzoylbenzyl Methylphosphonate 

Relevant academic research and scientific papers

The catalytic asymmetric abramov reaction

The first catalytic enantioselective Abramov reaction is described. The process is based on the utilization of a chiral disulfonimide catalyst, which efficiently avoids the difficulties encountered with metal-based catalysts. Several functionalized a-hydroxy phosphonates were synthesized in good yields and with excellent enantiomeric ratios of up to > 99:1. The process was shown to be scalable and up to 1 g of starting material could be employed under mild reaction conditions.

Method for the esterification of P-O components

The present invention is directed to a new method for esterification of P-O components. More specifically, the present invention relates to a new method for esterification of P-O components containing at least one P-O-H functional group, whereby the P-O-H functional group(s) is converted into P-O-R functional group(s). The method according to the invention may find particular use in the manufacture of diesters of phosphorous acid.

Synthesis of novel benzosuberone derivatives using organophosphorus reagents and their antitumor activities

2-Arylidenebenzosuberones react with a Wittig-Horner reagent in the presence of sodium hydride as a base to give the novel dimethyl (4-(4-methoxyphenyl)-2-oxa-2,3,4,5,6,7-hexahydrobenzo-[6,7]cyclohepta[1,2-b] pyran-3-yl)phosphonate. On the other hand, 6,7-dihydrobenzo[6,7]cyclohepta-[1,2- b]pyran-2(5H)-ones were isolated from the reaction of 2-arylidenebenzosuberones with Wittig-Horner reagents using alcoholic sodium alkoxide. The reaction of 2-arylidenebenzosuberones with trialkyl phosphites affords the alkyl phosphonate derivatives. Tris(dialkylamino)phosphines react with 2-arylidenebenzosuberones to give the oxaphospholanoxide products. 2-Arylidenebenzosuberones react with Lawesson's reagent to yield the corresponding dimers. Some of the prepared products were screened for antitumor activity.

Synthesis of H-phosphinates by the UV light - Mediated fragmentation- related phosphorylation using simple P-heterocycles

Photolysis of aryl-substituted 2,5-dihydrophosphole oxides (5a-e and 8) in the presence of methanol afforded methyl aryl-H-phosphinates (2a-e) in good yields. In the case of 1-ethyl-, cyclohexyl-, or ethoxy-2,5-dihydrophosphole oxides, the reaction was mu

Synthesis of mixed alkylphosphites and alkylphosphates

Some mixed phosphites having two different alkyl chain were obtained as forerunners for mixed phosphates Mixed dialkyl phosphates were obtained in good yields (40-80%) by phase transfer catalysis in liquid-liquid sistem, starting from different dialkyl phosphites and aliphatic alcohols. The reaction conditions were optimized in order to obtain good yields in phosphites and phosphates respectively. Compounds were analyzed by IR, P31-NMR.

ALKYLATING PROPERTIES OF DIALKYL PHOSPHITES

When the mixture of amines and dialkyl phosphites is used in the reaction, as for example in the Kabachnik-Fields reaction, all possible N-alkylated products are formed.N-ethylation by diethyl phosphite is much slower than N-methylation by dimethyl phosphite and the latter can be easily formed via transesterification when the methanol is present in the mixture.Key words: Amine alkylation, dialkyl phosphites, Kabachnik-Fields synthesis.