
Tetrahedron Letters p. 9323 - 9326 (1994)
Update date:2022-08-05
Topics:
Wang, Xui
Monte, William T.
Napier, James J.
Ghannam, Ameen
(TMS)ethyl malonate can be generated in-situ by treating potassium ethyl malonate with trimethylsilyl chloride and acylated with aliphatic or aromatic acyl imidazoles or chlorides in the presence of DBU to prepare a variety of β-ketoesters. This constitutes a high yield method for preparing β-ketoesters, which also can be extended to the formation of alkylidene malonates.
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