1610375-30-8

Upstream product

• 124-38-9 carbon dioxide 
• 100-39-0 benzyl bromide 
• 27491-70-9 dimethyl diazomethylphosphonate 
• 57443-18-2 benzyl 2-(dimethoxyphosphoryl)acetate 

Downstream Products

• 1610375-32-0 benzyl 2-(dimethoxyphosphoryl)-2-(((1S,4R)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)cyclopent-2-en-1-yl)oxy)acetate 
• 1610375-33-1 (((2-(benzyloxy)-1-(((1S,4R)-4-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)cyclopent-2-en-1-yl)oxy)-2-oxoethyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate) 
• 1610375-31-9 benzyl 2-(((1S,4R)-4-acetoxycyclopent-2-en-1-yl)oxy)-2-(dimethoxyphosphoryl)acetate 

Relevant academic research and scientific papers

Direct Carboxylation of the Diazo Group ipso-C(sp2)-H bond with Carbon Dioxide: Access to Unsymmetrical Diazomalonates and Derivatives

The direct carboxylation of the ipso-C(sp2)-H bond of a diazo compound with carbon dioxide under mild reaction conditions is described. This method is transition-metal-free, uses a weak base, and proceeds at ambient temperature under atmospheric pressure in carbon dioxide. The carboxylation exhibits high reactivity and is amenable to subsequent diversification. A series of unsymmetrical 1,3-diester/keto/amide diazo compounds are obtained with moderate to excellent yields (up to 99%) with good functional group compatibility.

PHOSPHONUCLEOSIDES USEFUL IN THE TREATMENT OF VIRAL DISORDERS

A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or prodrug thereof, wherein the groups are as defined in the claims. Further aspects of the invention relate to pharmaceutical compositions comprising compounds of formula (I), and the use of compounds of formula (I) in the preparation of a medicament for treating a viral disorder.