161064-07-9Relevant academic research and scientific papers
Synthesis of 5-Vinyl-2-isoxazolines by Palladium-Catalyzed Intramolecular O-Allylation of Ketoximes
Fernandes, Rodney A.,Gangani, Ashvin J.,Panja, Arpita
, p. 6227 - 6231 (2021/08/18)
An efficient method for the synthesis of 5-vinyl-2-isoxazolines by Pd-catalyzed intramolecular O-allylation of ketoximes has been developed. The reaction involves Pd(0)-catalyzed π-allyl formation via leaving group ionization or Pd(II)-catalyzed allylic C-H activation followed by intramolecular nucleophilic oxime oxygen attack. This methodology has been elaborated to various value-added products by epoxidation, Wacker oxidation, cross-metathesis, hydroboration-oxidation, dihydroxylation, and catalytic hydrogenation.
Anionic domino C-O-heterocyclization approach for the synthesis of 5-vinyl isoxazolines
Qazi, Naveed Ahmed,Singh, Parvinder Pal,Jan, Sumira,Kumar, H. M. Sampath
, p. 1449 - 1451 (2008/02/13)
5-Vinyl isoxazolines were isolated in high yields through domino nucleophilic addition-anionic C-O-heterocyclization, when allyl organometallics derived from trans-1,4-dihalobutene were reacted with nitrile oxides. Georg Thieme Verlag Stuttgart.
Conformationally restrained β-blocking oxime ethers. 2. Synthesis and β-adrenergic properties of diastereoisomeric anti and syn 2-(5'-(3'-aryl-substituted)isoxazolidinyl)-N-alkylethanolamines
Balsamo,Breschi,Chiellini,Lucacchini,Macchia,Martinelli,Martini,Nardini,Orlandini,Romagnoli,Rossello
, p. 855 - 867 (2007/10/02)
The diastereoisomeric 2-(5'-(3'-aryl)isoxazolidinyl)ethaolamines 1c-h-4c-h were synthesized as analogs of the corresponding P-blocking isoxazolines unsubstituted on the aromatic ring 1a-4a, with the aim of checking the effects on the adrenergic properties
