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161261-55-8

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161261-55-8 Usage

General Description

1-(2-hydroxyethyl)-1H-indole-3-carbaldehyde is a chemical compound that belongs to the class of indole derivatives. It has a molecular formula C11H11NO2 and a molecular weight of 189.21 g/mol. 1-(2-hydroxyethyl)-1H-indole-3-carbaldehyde is a yellowish to orange colored solid, and it is used in the pharmaceutical and chemical industries as an intermediate for the synthesis of various bioactive compounds. It is also used in research laboratories as a reagent in organic synthesis. The presence of a hydroxyethyl group and an aldehyde functional group in its structure makes it a versatile building block for the preparation of various complex organic molecules.

Check Digit Verification of cas no

The CAS Registry Mumber 161261-55-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,2,6 and 1 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 161261-55:
(8*1)+(7*6)+(6*1)+(5*2)+(4*6)+(3*1)+(2*5)+(1*5)=108
108 % 10 = 8
So 161261-55-8 is a valid CAS Registry Number.

161261-55-8Downstream Products

161261-55-8Relevant articles and documents

N-(Hydroxyalkyl) derivatives of tris(1H-indol-3-yl)methylium salts as promising antibacterial agents: Synthesis and biological evaluation

Lavrenov, Sergey N.,Isakova, Elena B.,Panov, Alexey A.,Simonov, Alexander Y.,Tatarskiy, Viktor V.,Trenin, Alexey S.

, p. 1 - 13 (2020/12/29)

The wide spread of pathogens resistance requires the development of new antimicrobial agents capable of overcoming drug resistance. The main objective of the study is to elucidate the effect of substitutions in tris(1H-indol-3-yl)methylium derivatives on their antibacterial activity and toxicity to human cells. A series of new compounds were synthesized and tested. Their antibacterial activity in vitro was performed on 12 bacterial strains, including drug resistant strains, that were clinical isolates or collection strains. The cytotoxic effect of the compounds was determined using an test with HPF-hTERT (human postnatal fibroblasts, immortalized with hTERT) cells. The activity of the obtained compounds depended on the carbon chain length. Derivatives with C5–C6 chains were more active. The minimum inhibitory concentration (MIC) of the most active compound on Gram-positive bacteria, including MRSA, was 0.5 μg/mL. Compounds with C5–C6 chains also revealed high activity against Staphylococcus epidermidis (1.0 and 0.5 μg/mL, respectively) and moderate activity against Gram-negative bacteria Escherichia coli (8 μg/mL) and Klebsiella pneumonia (2 and 8 μg/mL, respectively). However, they have no activity against Salmonella cholerasuis and Pseudomonas aeruginosa. The most active compounds revealed higher antibacterial activity on MRSA than the reference drug levofloxacin, and their ratio between antibacterial and cytotoxic activity exceeded 10 times. The data obtained provide a basis for further study of this promising group of substances.

Aerobic transition-metal-free visible-light photoredox indole C-3 formylation reaction

Li, Xiang,Gu, Xiangyong,Li, Yongjuan,Li, Pixu

, p. 1897 - 1900 (2014/06/24)

An aerobic visible-light-promoted indole C-3 formylation reaction catalyzed by Rose Bengal has been developed. This transition-metal-free process employs molecular oxygen as the terminal oxidant and uses TMEDA as the one-carbon source through C-N bond cleavage. The reaction is compatible with a variety of functional groups.

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