1612838-57-9

Basic information

• Product Name: 2-fluoro-1-phenyl-2-(p-tolyl)ethan-1-one
• Synonyms: 2-fluoro-1-phenyl-2-(p-tolyl)ethan-1-one
• CAS NO: 1612838-57-9
• Molecular Weight: 228.266
• Mol File: 1612838-57-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-fluoro-1-phenyl-2-(p-tolyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-1-phenyl-2-(p-tolyl)ethan-1-one(1612838-57-9)
• EPA Substance Registry System: 2-fluoro-1-phenyl-2-(p-tolyl)ethan-1-one(1612838-57-9)

Safety Data

• Hazardous Substances Data: 1612838-57-9(Hazardous Substances Data)

Upstream product

• 41463-86-9 4,4,4-trifluoro-3-hydroxy-1-phenylbut-2-en-1-one 
• 321-75-5 α-bromo-α-fluorophenylethanone 
• 5720-05-8 4-methylphenylboronic acid 
• 18412-57-2 p-tolyltriethoxysilane 
• 98-86-2 acetophenone 
• 450-95-3 2-fluoroacetophenone 
• 106-38-7 para-bromotoluene 
• 106-43-4 para-chlorotoluene 
• 4714-21-0 4-methylstilbene 

Relevant articles and documents

Preparation method of monofluorobromoacetone derivative

The invention relates to a preparation method of a monofluorobromoacetone derivative. The method comprises the following steps: mixing a compound as shown in a formula (1) with a catalyst, a ligand, alkali and a solvent, performing reacting with a compound as shown in a formula (2) under the protection of N2 until the reaction is complete, extracting and separating the obtained reaction solution to obtain the monofluorobromoacetone derivative as shown in a formula (3), wherein R1 is phenyl, substituted phenyl or heterocyclic ring; R2 is phenyl or substituted phenyl. Compared with the prior art, the method has the advantages of high reaction selectivity, milder conditions and shorter reaction time.

Palladium-catalyzed direct mono-α-arylation of α-fluoroketones with aryl halides or phenyl triflate

A palladium catalyzed Negishi-type α-arylation of α-fluoroketones with electron-rich and electron-deficient aryl halides or phenyl triflate has been developed. This direct mono-α-arylation method generate a variety of ternary α-aryl-α-monofluoroketones easily in good to excellent yields using XPhos as ligand and Cs2CO3as mild base.