1613317-35-3

Upstream product

• 1613219-39-8 7-(4-phenylthiazol-2-yl)-naphthalene-2-carboxylic acid 
• 75-65-0 tert-butyl alcohol 
• 58556-75-5 2,7-dibromonaphthalene 
• 5043-14-1 7-bromonaphthalene-2-carboxylic acid 
• 5159-63-7 7-bromo-naphthalene-2-carboxylic acid methyl ester 
• 1613219-65-0 7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-naphthalene-2-carboxylic acid methyl ester 
• 1613219-66-1 7-(4-phenylthiazol-2-yl)-naphthalene-2-carboxylic acid methyl ester 

Downstream Products

• 1613317-36-4 7-(4-phenylthiazol-2-yl)naphthalen-2-ylamine 
• 1613317-20-6 2-cyclohexyl-N-[7-(4-phenylthiazol-2-yl)naphthalen-2-yl]succinamic acid 

Relevant academic research and scientific papers

SUBSTITUTED THIAZOLE COMPOUNDS

The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are LMP7 inhibitors and may be useful in treating associated inflammatory diseases and disorders such as, for example, rheumatoid arthritis, lupus and irritable bowel disease.