16150-44-0Relevant articles and documents
Development of advanced chemometric-assisted spectrophotometric methods for the determination of cromolyn sodium and its alkaline degradation products
El Zahar, Noha M.,Tadros, Mariam M.,Ayoub, Bassam M.
, (2020)
Advanced and sensitive spectrophotometric and chemometric analytical methods were successfully established for the stability-indicating assay of cromolyn sodium (CS) and its alkaline degradation products (Deg1 and Deg2). Spectrophotometric mean centering ratio spectra method (MCR) and chemometric methods, including principal component regression (PCR) and partial least square (PLS-2) methods, were applied. Peak amplitudes after MCR at 367.8 nm, 373.8 nm and 310.6 nm were used within linear concentration ranges of 2–40 μg mL-1, 5–40 μg mL-1 and 10–100 μg mL-1 for CS, Deg1 and Deg2, respectively. For PCR and PLS-2 models, a calibration set of eighteen mixtures and a validation set of seven mixtures were built for the simultaneous determination of CS, Deg1 and Deg2 in the ranges of 5–13 μg mL-1, 8–16 μg mL-1, and 10–30 μg mL-1, respectively. The authors emphasize the importance of a stability-indicating strategy for the investigation of pharmaceutical products.
Synthesis and antifungal activity of 1,3-bis<2- or 4-(substituted cinnamoyl or 1-acyl-4,5-dihydro-5-substituted phenyl-1H-pyrazol-3-yl)phenoxy-2-propanols and related compounds
Sangwan, Naresh K,Verma, Braham S,Dhindsa, Kuldip Singh
, p. 590 - 594 (2007/10/02)
Condensation of 1,3-bis(2- or 4-acetylphenoxy or 2-acetyl-3-hydroxyphenoxy)-2-propanol (IIa-c), prepared from 2- or 4-hydroxy- or 2,6-dihydroxyacetophenone (Ia-c) and chloromethyloxirane, with substituted benzaldehydes gives the corresponding 1,3-bis-2-propanols (IIIa-i).Isomerization of the phenols IIIg-i with silica gel in solid phase furnishes the corresponding 1,3-bis(2-aryl-2,3-dihydro-4-oxo-4H-1-benzopyran-5-yloxy)-2-propanols (IVa-c).Condensation of IIIa-i with hydrazine in refluxing formic or acetic acid affords thecorresponding substituted 1,3-bis(2- or 4-(1-acyl-4,5-dihydro-5-substituted phenyl-1H-pyrazol-3-yl)phenoxy>-2-propanols (VIa-r).Alkylation of IIIg-i and VIg,h and VIp with ethylchloroacetate gives the corresponding bisacetic acid esters Va-c and VIIa-c respectively.Some of the tested compounds exhibit in vitro growth inhibitory activity against Curvularia ovoidea and Rhizoctonia solani at concentrations of 25-50 μg/ml.