16151-04-5

Upstream product

• 58010-22-3 4,6-Di(p-tolyl)-1,2,3,5-oxathiadiazin-2,2-dioxid 
• 19227-13-5 p-toluamidoxime 
• 874-60-2 4-methyl-benzoyl chloride 
• 814-68-6 acryloyl chloride 
• 61713-81-3 3,5-bis(p-tolyl)-1,2,4-oxadiazole-4-oxide 
• 1165952-91-9 cyclohexa-1,3-diene 
• 104-87-0 4-methyl-benzaldehyde 
• 104-81-4 4-Methylbenzyl bromide 
• 3235-02-7 p-methylbenzaldehyde oxime 
• 104-85-8 para-methylbenzonitrile 
• 19227-13-5 (Z)-N'-hydroxy-4-methylbenzimidamide 
• 188118-36-7 N,N-Diethyl-N'-hydroxy-4-methyl-benzamidine 
• 36288-37-6 N-hydroxy-4-methylbenzenecarboximidoyl chloride 
• 132033-35-3 4-Methylbenz(N-acetyl))imidsaeure-ethylester 

Downstream Products

• 53349-69-2 5-{4-[trans-2-(2-phenyl-benzofuran-6-yl)-vinyl]-phenyl}-3-p-tolyl-[1,2,4]oxadiazole 
• 16157-11-2 5-[4-(trans-2-biphenyl-4-yl-vinyl)-phenyl]-3-p-tolyl-[1,2,4]oxadiazole 
• 16157-13-4 3,5-bis-[4-(trans-2-biphenyl-4-yl-vinyl)-phenyl]-[1,2,4]oxadiazole 
• 16157-10-1 5-(4-trans-styryl-phenyl)-3-p-tolyl-[1,2,4]oxadiazole 
• 16157-12-3 3,5-bis-(4-trans-styryl-phenyl)-[1,2,4]oxadiazole 
• 53349-63-6 5-[4-(4-trans-styryl-trans-styryl)-phenyl]-3-p-tolyl-[1,2,4]oxadiazole 
• 53349-66-9 5-[4-(4-benzofuran-2-yl-trans-styryl)-phenyl]-3-p-tolyl-[1,2,4]oxadiazole 
• 52596-53-9 2-{4-[4-(3-p-tolyl-[1,2,4]oxadiazol-5-yl)-trans-styryl]-phenyl}-2H-benzo[1,2,3]triazole 
• 65964-82-1 2-phenyl-7-[4-(3-p-tolyl-[1,2,4]oxadiazol-5-yl)-styryl]-[1,2,4]triazolo[1,5-a]pyridine 
• 65204-75-3 5-{4-[4-(5-chloro-2-phenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-3-p-tolyl-[1,2,4]oxadiazole 
• 65204-90-2 5-{4-[4-(4-chloro-5-phenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-3-p-tolyl-[1,2,4]oxadiazole 
• 65204-81-1 5-{4-[4-(2,5-diphenyl-2H-[1,2,3]triazol-4-yl)-styryl]-phenyl}-3-p-tolyl-[1,2,4]oxadiazole 
• 65204-95-7 5-{4-[4-(4,5-diphenyl-[1,2,3]triazol-2-yl)-styryl]-phenyl}-3-p-tolyl-[1,2,4]oxadiazole 
• 61520-00-1 5-{4-[2-(2-phenyl-2H-[1,2,3]triazol-4-yl)-vinyl]-phenyl}-3-p-tolyl-[1,2,4]oxadiazole 

Relevant academic research and scientific papers

Microwave-assisted efficient, one-pot, three-component synthesis of 3,5-disubstituted 1,2,4-oxadiazoles under solvent-free conditions

A novel synthesis of 1,2,4-oxadiazoles is described from a one-pot, three-component reaction between nitriles, hydroxylamine, and aldehydes under microwave irradiation and solvent-free conditions in excellent yields.

Selective oxidative deoximation with anhydrous Ce(IV) sulfate

Anhydrous Ce(SO4)2 in chloroform selectively converts oximes into the parent carbonyl compounds in good yields. Hammett correlations helped to indicate a plausible mechanism for the above reaction. The formation of 1-(dinitromethyl)benzene was assumed to be a product of isonitroso hydrogen reaction with arylaldoximes.

An efficient method for the one-pot tandem synthesis of 3,5-disubstituted-1,2,4-oxadiazoles from benzyl halides

The first example of a one-pot tandem approach for the synthesis of 3,5-disubstituted-1,2,4-oxadiazole derivatives from benzyl halides and amidoxime is reported. Derivatives of 3,5-disubstituted 1,2,4-oxadiazole were obtained in excellent yields under mil

Br?nsted acid-catalyzed simple and efficient synthesis of 1,2,4-triazoles and 1,2,4-oxadiazoles using 2,2,2-trichloroethyl imidates in PEG

A facile and highly efficient synthesis of 3,4,5-trisubstituted 1,2,4-triazoles and 3,5-disubstituted 1,2,4-oxadiazoles from 2,2,2-trichloroethyl imidates using PEG as a solvent and employing PTSA as the catalyst under mild conditions is described.

One-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles directly from nitrile and hydroxylamine hydrochloride under solvent-free conditions using potassium fluoride as catalyst and solid support

A one-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles with two identical substituents directly from the reaction of nitriles and hydroxylamine hydrochloride in the presence of potassium fluoride as catalyst and solid support under solvent-free condit

New one step synthesis of 3,5-disubstituted 1,2,4-oxadiazoles

(Chemical Equation Presented) Disubstituted 1,2,4-oxadiazoles have been synthesized in good yields and good purity in one pot procedure by reaction of aromatic nitriles, hydroxylamine hydrochloride and sodium carbonate in ethylene glycol under heating at

Novel synthesis of 1,2,4-oxadiazoles by condensation of arylamidoximes with N-substituted iminoethers

A new efficient route to 3,5-disubstituted-1,2,4-oxadiazoles 4a-j has been performed via the one-step reaction between arylamidoximes 1a-e and N-substituted iminoethers 2a-c. The structures of compounds 4 have been elucidated by mass spectrometry, infrared and 1H, 13C NMR measurements.

A photochemical generation of nitrosocarbonyl intermediates

Nitrosocarbonyl intermediates are photochemically generated from 1,2,4- oxadiazole-4-oxides and efficiently trapped with enes and dienes.

Cycloadditions of nitrile oxides to amidoximes. A general synthesis of 3,5-disubstituted 1,2,4-oxadiazole-4-oxides

The cycloaddition of nitrile oxides to amidoximes is a general method for the synthesis of 3,5-disubstituted 1,2,4-oxadiazole-4-oxides with the same or different substituents. The yields are only moderate since an equivalent amount of the nitrile oxide is consumed by reaction with the amine released in the fragmentation of the primary cycloadducts and reforms the amidoxime. With excess nitrile oxides the 1,2,4-oxadiazole-4-oxides undergo a disproportionation reaction to yield nitroso carbonyl intermediates and 1,2,4-oxadiazoles.

A Simplified Procedure for Preparing 3,5-Disubstituted-1,2,4-Oxadiazoles by Reaction of Amidoximes with Acyl Chlorides in Pyridine Solution

3-R-5-R'-1,2,4-Oxadiazoles are prepared in fair to good yield by short-time, one-pot reaction of an amidoxime, RC(NH2)NOH, with an acyl chloride, R'COCl, in pyridine solution.Precipitation of the oxadiazole occurs on diluting the pyridine reaction solutio