1616058-75-3Relevant academic research and scientific papers
Light-mediated copper-catalyzed phosphorus/halogen exchange in 1,1-difluoroalkylphosphonium salts
Panferova, Liubov I.,Levin, Vitalij V.,Struchkova, Marina I.,Dilman, Alexander D.
supporting information, p. 1314 - 1317 (2019/01/30)
A method for the assembly of the halodifluoromethyl group (CF2X, X = Cl, Br, I) is described. The reaction involves the light-mediated substitution of the triphenylphosphine by halide anions in readily accessible gem-difluorinated phosphonium s
Lithium triethylborohydride-promoted generation of α,α-difluoroenolates from 2-iodo-2,2-difluoroacetophenones: An unprecedented utilization of lithium triethylborohydride
Peng, Peng,Wu, Jing-Jing,Liang, Jun-Qing,Zhang, Tian-Yu,Huang, Jin-Wen,Wu, Fan-Hong
, p. 56034 - 56037 (2017/12/26)
Lithium triethylborohydride was found to promote the generation of α,α-difluoroenolates from 2-iodo-2,2-difluoroacetophenones, and applied to the synthesis of polyfluorinated β-hydroxy ketones via self-condensation or aldol reaction. The reaction indicate
Nucleophilic Iododifluoromethylation of Carbonyl Compounds Using Difluoromethyl 2-Pyridyl Sulfone
Miao, Wenjun,Ni, Chuanfa,Zhao, Yanchuan,Hu, Jinbo
supporting information, p. 2766 - 2769 (2016/06/15)
A new, efficient method for iododifluoromethylation of carbonyl compounds utilizing difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H) is described. This transformation is achieved by a nucleophilic addition of 2-PySO2CF2
Nucleophilic Iododifluoromethylation of Aldehydes Using Bromine/Iodine Exchange
Levin, Vitalij V.,Smirnov, Vladimir O.,Struchkova, Marina I.,Dilman, Alexander D.
, p. 9349 - 9353 (2015/09/28)
A method for the iododifluoromethylation of aromatic aldehydes using (bromodifluoromethyl)trimethylsilane (Me3SiCF2Br) is described. The selective formation of the CF2I group is based on using sodium iodide, with the sodium serving as a scavenger of bromide and iodide serving as a nucleophile with respect to difluorocarbene. The primary CF2I-addition products can undergo HI-elimination or iodine/zinc exchange followed by allylation in a one-pot manner.
Nucleophilic bromo- and iododifluoromethylation of aldehydes
Kosobokov, Mikhail D.,Levin, Vitalij V.,Struchkova, Marina I.,Dilman, Alexander D.
supporting information, p. 3784 - 3787 (2014/08/05)
A method for bromo- and iododifluoromethylation of aldehydes using bromo- and iodo-substituted difluoromethyl silicon reagents (Me3SiCF 2X) is described. The reaction is performed in the presence of a combination of tetrabutylammonium and lithium salts Bu4NX/LiX (X = Br or I) in propionitrile. It is believed that, in this process, a short-lived halodifluoromethyl carbanion serves as nucleophile, which is reversibly generated from difluorocarbene and a halide anion.
