115591-64-5

Basic information

• Product Name: methyl 4-chloro-3-(trifluoromethyl)benzoate
• Synonyms: benzoic acid, 4-chloro-3-(trifluoromethyl)-, methyl ester
• CAS NO: 115591-64-5
• Molecular Formula: C₉H₆ClF₃O₂
• Molecular Weight: 238.5909
• Mol File: 115591-64-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 246.3°C at 760 mmHg
• Flash Point: 97.3°C
• Density: 1.38g/cm³
• Vapor Pressure: 0.0273mmHg at 25°C
• Refractive Index: 1.466
• CAS DataBase Reference: methyl 4-chloro-3-(trifluoromethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-chloro-3-(trifluoromethyl)benzoate(115591-64-5)
• EPA Substance Registry System: methyl 4-chloro-3-(trifluoromethyl)benzoate(115591-64-5)

Safety Data

• Hazardous Substances Data: 115591-64-5(Hazardous Substances Data)

Upstream product

• 1126-46-1 Methyl 4-chlorobenzoate 
• 76-05-1 trifluoroacetic acid 
• 186581-53-3 diazomethane 
• 1737-36-6 4-chloro-3-(trifluoromethyl)benzoic acid 
• 623-03-0 4-Cyanochlorobenzene 
• 1735-54-2 4-chloro-3-(trifluoromethyl)benzonitrile 
• 913835-92-4 (2-chloro-5-(methoxycarbonyl)phenyl)boronic acid 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 67-56-1 methanol 
• 497-19-8 sodium carbonate 

Downstream Products

• 458549-89-8 4-chloro-3-(trifluoromethyl)benzohydrazide 
• 1206123-55-8 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid 
• 1206123-97-8 (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid, L-arginine salt 
• 1206123-37-6 [(3R)-7-{[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy}-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid 
• 1206124-34-6 (R/S)-ethyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate 
• 957205-39-9 (4-cyclopentyl-3-(trifluoromethyl)phenyl)methanol 
• 957208-65-0 4-(chloromethyl)-1-cyclopentyl-2-(trifluoromethyl)benzene 
• 161622-16-8 methyl 4-cyclopentyl-3-(trifluoromethyl)benzoate 
• 1206124-73-3 methyl 4-(cyclohexylmethyl)-3-(trifluoromethyl)benzoate 
• 1215118-87-8 tert-butyl 2-(7-(4-(cyclohexylmethyl)-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate 
• 1215118-86-7 4-(chloromethyl)-1-(cyclohexylmethyl)-2-(trifluoromethyl)benzene 
• 1215118-35-6 2-(7-(4-(cyclohexylmethyl)-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid 
• 1206124-75-5 (4-(cyclohexylmethyl)-3-(trifluoromethyl)phenyl)methanol 

Relevant articles and documents

COMPOUNDS

A compound for use in the treatment of a disease ameliorated by the inhibition of Notum of formula (I): (I)

Silver-Catalyzed C-H Trifluoromethylation of Arenes Using Trifluoroacetic Acid as the Trifluoromethylating Reagent

Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove useful in other contexts and could potentially be extended to other trifluoromethylation reactions. (Chemical Equation Presented).

2H-CHROMENE COMPOUND AND DERIVATIVE THEREOF

[Object] Provided is a compound which has an excellent S1P1 agonist action, and is useful particularly as an active ingredient for an agent for preventing and/or treating a disease induced by undesirable lymphocyte infiltration or a disease ind