1617530-91-2

Upstream product

• 132819-92-2 1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 3770-50-1 2-carbethoxyindole 

Downstream Products

• 1617530-99-0 3-(4-chlorobenzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-10-8 (Z)-3-(4-chlorobenzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-01-7 (E)-3-(4-(benzyloxy)benzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-12-0 (Z)-3-(4-(benzyloxy)benzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-03-9 (E)-3-(4-methoxybenzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-14-2 (Z)-3-(4-methoxybenzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-05-1 (E)-3-(4-methylbenzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-16-4 (Z)-3-(4-methylbenzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-08-4 (E)-3-(4-nitrobenzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617530-92-3 dimethyl ((1-tosyl-1H-indol-2-yl)methyl)phosphonate 

Relevant academic research and scientific papers

Chromium-Catalyzed Asymmetric Dearomatization-Addition Reactions of Halomethyloxazoles and Indoles

The asymmetric dearomatization-addition reaction of halomethyloxazoles and halomethylindoles with aldehydes is realized in the presence of a carbazole-based bisoxazoline CrCl 2 complex to afford the corresponding enantioenriched, hydroxylated oxazoline and indoline products. The observed excellent chemo-, regio-, diastereo- and enantioselectivities are notable advantages of this protocol. The strategy established in this study is expected to find application in the synthesis of azaheterocycles with biological significance and useful functionalities.

Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route, enabling the assembly of a mini-library of structural analogues. The first single crystal X-ray structural determination on a member of this series is reported along with SAR studies identifying potent inhibitors of invasion and replication of the parasitic protozoan Toxoplasma gondii.

Total synthesis of the cyanobacterial metabolite nostodione A: Discovery of its antiparasitic activity against Toxoplasma gondii

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route. A small assemblage of structural analogues were prepared and their cytotoxicity and anti-invasion activity against the protozoal parasite Toxoplasma gondii is reported for the first time. This journal is the Partner Organisations 2014.