1617531-14-2

Upstream product

• 1617530-94-5 dimethyl ((1H-indol-2-yl)methyl)phosphonate 
• 1617530-92-3 dimethyl ((1-tosyl-1H-indol-2-yl)methyl)phosphonate 
• 1617530-91-2 N-p-toluenesulfonyl-2-chloromethylindole 
• 132819-92-2 1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester 
• 3770-50-1 2-carbethoxyindole 
• 1617530-97-8 dimethyl 1,2-dioxo-1,2,3,4-tetrahydrocyclopenta[b]indol-3-ylphosphonate 
• 123-11-5 4-methoxy-benzaldehyde 
• 1617530-96-7 methyl 2-(2-((dimethoxyphosphoryl)methyl)-1H-indol-3-yl)-2-oxoacetate 
• 1617530-95-6 C₁₃H₁₃ClNO₅P 

Relevant academic research and scientific papers

Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route, enabling the assembly of a mini-library of structural analogues. The first single crystal X-ray structural determination on a member of this series is reported along with SAR studies identifying potent inhibitors of invasion and replication of the parasitic protozoan Toxoplasma gondii.

Total synthesis of the cyanobacterial metabolite nostodione A: Discovery of its antiparasitic activity against Toxoplasma gondii

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route. A small assemblage of structural analogues were prepared and their cytotoxicity and anti-invasion activity against the protozoal parasite Toxoplasma gondii is reported for the first time. This journal is the Partner Organisations 2014.