1617530-92-3

Upstream product

• 1617530-91-2 N-p-toluenesulfonyl-2-chloromethylindole 
• 121-45-9 phosphorous acid trimethyl ester 
• 868-85-9 Dimethyl phosphite 
• 132819-92-2 1-(toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 3770-50-1 2-carbethoxyindole 

Downstream Products

• 1617530-99-0 3-(4-chlorobenzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-10-8 (Z)-3-(4-chlorobenzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-01-7 (E)-3-(4-(benzyloxy)benzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-12-0 (Z)-3-(4-(benzyloxy)benzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-03-9 (E)-3-(4-methoxybenzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-14-2 (Z)-3-(4-methoxybenzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-05-1 (E)-3-(4-methylbenzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-16-4 (Z)-3-(4-methylbenzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 
• 1617531-08-4 (E)-3-(4-nitrobenzylidene)cyclopenta[b]indole-1,2(3H,4H)-dione 

Relevant academic research and scientific papers

Copper-catalyzed decarboxylative cyclization: Via tandem C-P and C-N bond formation: Access to 2-phosphorylmethyl indoles

A novel copper-catalyzed decarboxylative cyclization of ethynyl benzoxazinanones with P(O)H compounds has been developed. This protocol leads to a series of 2-phosphorylmethyl indoles with high efficiency and selectivity (up to 99% yield) through tandem C-P/C-N bond formation under mild conditions.

Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route, enabling the assembly of a mini-library of structural analogues. The first single crystal X-ray structural determination on a member of this series is reported along with SAR studies identifying potent inhibitors of invasion and replication of the parasitic protozoan Toxoplasma gondii.

Total synthesis of the cyanobacterial metabolite nostodione A: Discovery of its antiparasitic activity against Toxoplasma gondii

A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route. A small assemblage of structural analogues were prepared and their cytotoxicity and anti-invasion activity against the protozoal parasite Toxoplasma gondii is reported for the first time. This journal is the Partner Organisations 2014.