16179-41-2

Basic information

• Product Name: Decanoic acid, 2-hydroxyethyl ester
• Synonyms: capric acid 2-hydroxyethyl ester;glycol decanoate;Decansaeure-(2-hydroxy-aethylester);Decanoic acid,2-hydroxyethyl ester
• CAS NO: 16179-41-2
• Molecular Formula: C12H24O3
• Molecular Weight: 216.321
• Mol File: 16179-41-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Decanoic acid, 2-hydroxyethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Decanoic acid, 2-hydroxyethyl ester(16179-41-2)
• EPA Substance Registry System: Decanoic acid, 2-hydroxyethyl ester(16179-41-2)

Safety Data

• Hazardous Substances Data: 16179-41-2(Hazardous Substances Data)

Usage

Uses

Ethylene Glycol Monodecanoate was used as a reactant in the synthesis of water-woluble phospholipid analogues as inhibitors of phospholipase C.

Upstream product

• 35438-71-2 triglycol borate 
• 334-48-5 1-decanoic acid 
• 96-49-1 [1,3]-dioxolan-2-one 
• 107-21-1 ethylene glycol 
• 112-13-0 n-decanoyl chloride 
• 4353-06-4 2-n-nonyl-1,3-dioxolane 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 1246007-06-6 C₂₈H₃₈F₂N₇O₆P 

Relevant articles and documents

Voriconazole derivative, synthesis thereof, and use thereof in long-acting preparation

The invention relates to a compound of formula (I), and a salt, an N-oxide, a quaternary ammonium and a stereoisomer thereof. R to R in the formula (I) are as defined in claims. The invention also relates to an intermediate for preparing the compound of formula (I), and a method for preparing the compound of formula (I). The invention further relates to a use of the compound of formula (I) as a drug especially used for preventing or treating fungal infection.

Posaconazole derivative, synthesis and application in prolonged action preparation thereof

The invention relates to a posaconazole derivative, synthesis and an application in a prolonged action thereof. The invention relates to a formula of a compound and salt, N-oxide, quaternary ammonium and stereoisomer of the compound, wherein R1-R8 are defined according to what is claimed. The invention also relates to a preparation formula of an intermediate body and a method of the compound. The invention further relates to a formula of an application of the compound as a drug, especially the application in preventing or treating fungal infection. The detailed formulas are in the specification.

Combinatorial synthesis of PEG oligomer libraries

A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.