161807-18-7

Usage

Uses

Used in Chemical Research:
(6-Chloro-pyridin-2-yl)-acetic acid methyl ester is used as a research compound for the synthesis and study of various organic molecules. Its unique structure allows for the exploration of new chemical reactions and the development of novel compounds with potential applications in different fields.
Used in Pharmaceutical Industry:
(6-Chloro-pyridin-2-yl)-acetic acid methyl ester is used as a building block in the development of new pharmaceuticals. Its structure can be incorporated into drug molecules to create new therapeutic agents with potential applications in the treatment of various diseases and conditions.
Used in Material Science:
(6-Chloro-pyridin-2-yl)-acetic acid methyl ester is used as a component in the synthesis of new materials with specific properties. Its incorporation into polymers or other materials can lead to the development of materials with improved characteristics, such as enhanced stability, reactivity, or selectivity.
Used in Agrochemical Industry:
(6-Chloro-pyridin-2-yl)-acetic acid methyl ester is used as a starting material in the synthesis of agrochemicals, such as pesticides or herbicides. Its unique structure can contribute to the development of more effective and environmentally friendly products for agricultural use.
Used in Dye and Pigment Industry:
(6-Chloro-pyridin-2-yl)-acetic acid methyl ester is used as a precursor in the production of dyes and pigments. Its chemical properties can be exploited to create new colorants with improved performance, such as higher color intensity, stability, or resistance to fading.

Upstream product

• 18368-63-3 6-chloro-2-picoline 
• 616-38-6 carbonic acid dimethyl ester 
• 67-56-1 methanol 
• 75279-60-6 2-(6-chloropyridin-2-yl)acetonitrile 
• 885267-14-1 2-(6-chloropyridin-2-yl)acetic acid 

Downstream Products

• 947381-03-5 methyl 7-chloro-[1,2,3]triazolo[1,5-a]pyridine-3-carboxylate 
• 947381-06-8 methyl 5-chloro-3-phenylindolizine-1-carboxylate 
• 947381-33-1 methyl 3-phenylindolizine-1-carboxylate 
• 1355052-41-3 C₂₀H₁₆FNO₃ 

Relevant academic research and scientific papers

TRIAZOLONE COMPOUNDS AND USES THEREOF

The invention disclosed herein is directed to compounds of Formula (I) and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of Formula (I), or a pharmaceutically acceptable salt thereof. The invention disclosed herein is also directed to methods of treating prostate, breast, ovarian, liver, kidney, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention disclosed herein is further directed to methods of treating prostate, breast, colon, pancreatic, chronic lymphocytic leukemia, melanoma and other cancers comprising administration of a of a therapeutically effective amount of a selective PPARα antagonist. The compounds and pharmaceutical compositions of the invention are also useful in the treatment of viral infections, such as HCV infections and HIV infections. The invention disclosed herein is also directed to a methods of preventing the onset of and/or recurrence of acute and chronic myeloid leukemia, as well as other cancers, comprising administration of a of a therapeutically effective amount of a selective PPARα antagonist.

Palladium-catalyzed decarboxylative couplings of 2-(2-Azaaryl)acetates with aryl halides and triflates

Pd-catalyzed decarboxylative cross-couplings of 2-(2-azaaryl)acetates with aryl halides and triflates have been discovered. This reaction is potentially useful for the synthesis of some functionalized pyridines, quinolines, pyrazines, benzoxazoles, and benzothiazoles. Theoretical analysis shows that the nitrogen atom at the 2-position of the heteroaromatics directly coordinates to Pd(II) in the decarboxylation transition state.

TRIAZOLE DERIVATIVE OR SALT THEREOF

[Problem] To provide a compound which may be used in treating diseases in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, especially diabetes and insulin resistance. [Means for Solution] It was found that a triazole derivative or a pharmaceutically acceptable salt thereof, in which the 3-position of triazole ring is substituted with a trisubstituted methyl group and the 5-position is substituted with a lower alkyl, cycloalkyl or the like, has a strong 11β-HSD1-inhibitory activity. In addition, since the triazole derivative of the present invention shows excellent blood glucose-lowering action, it may be used in the treatment of diabetes and insulin resistance.

TRIAZOLE DERIVATIVE OR SALT THEREOF

[Problem] There is provided a compound which can be used for therapy of diseases in which 11 β-hydroxysteroid dehydrogenase type 1(11β-HSD1) participates, in particular diabetes, insulin resistance. [Means for Solution] It has been found that a triazole derivative wherein the triazole ring is substituted with a trisubstituted methyl group in the 2-position or a pharmaceutically acceptable salt thereof has a strong 11β-HSD1 inhibitory activity. Moreover, the triazole derivative of the invention exhibits an excellent blood-glucose level-lowering action and hence can be used for therapy of diabetes, insulin resistance.

Catalytic asymmetric cyclopropanation of heteroaryldiazoacetates

Rh2(S-DOSP)4-catalyzed decomposition of heteroaryldiazoacetates in the presence of styrene results in highly diastereoselective and enantioselective cyclopropanations. Heteroaryldiazoacetates containing both electron-rich and electron-deficient heterocycles, such as thiophene, furan, pyridine, indole, oxazole, isoxazole, and benzoxazole, are effective in this chemistry. These studies broaden the range of diazo compounds containing both electron-withdrawing and electron-donating groups, which undergo highly diastereoselective cyclopropanations.

Conjugate Addition Reactions of Metallated Alkyl Pyridines. A Direct Route to 6-Substituted Pyridones

The conjugate addition of metallated alkylpyridines to enones followed by RaNi deprotection affords 6-substituted pyridones.