161871-65-4Relevant articles and documents
A new efficient synthesis of 3-nitropyridine and substituted derivatives
Bakke, Jan M.,Ranes, Eli
, p. 281 - 283 (1997)
Pyridine and pyridine derivatives have been nitrated in the β-position by reaction with N2O5 or NO2·BF4 in MeNO2, THF or MeCN to form the N-nitropyridinium salt. This was then reacted with an aqueous solution of a nucleophile to give the β-nitro compound in moderate to good yield.
ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG
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Page/Page column 94, (2015/06/03)
The present invention relates to aryl linked imidazole and triazole derivatives, compositions comprising said compounds, alone or in combination with other drugs, and methods of using the compounds for improving the pharmacokinetics of a drug. The compounds of the invention are useful in human and veterinary medicine for inhbiting CYP3A4 and for improving the pharmacokinetics of a therapeutic compound that is metabolized by CYP3A4.
7-Azacinnolin-4(1H)-one preparation and NMR studies of tautomery
Stockmann, Vegar,Primpke, Sebastian,Fiksdahl, Anne
experimental part, p. 737 - 741 (2011/07/31)
As part of our current investigations of nitropyridines, we hereby report the preparation of a new annulated heterocycle by C-azo coupling. Thus, the azacinnoline, pyrido[3,4-c]pyridazin-4(1H)-one (38%), was prepared from 4-acetyl-3-aminopyridine via diazotization. 1H, 13C, and 15N NMR spectroscopic investigations revealed that the azacinnoline exclusively exists in the NH-keto tautomeric form in DMSO-d6, CD 3OD, and D2O.