161987-83-3

Upstream product

• 100-39-0 benzyl bromide 
• 161987-82-2 ((3aR,6S,6aR)-6-Benzyloxymethyl-5-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-methanol 

Relevant academic research and scientific papers

Synthesis and anti-viral properties of 2',3'-dideoxy-3',4'- dihydroxymethyl substituted pyrimidine nucleoside analogues

Some 2',3'-dideoxy-3',4'-dihydroxymethyl nucleoside analogues have been synthesised starting from diacetone-D-glucose. The 3-C-hydroxymethyl group was introduced by selective hydroboration-oxidation of the 3-C-methylene derivative. The 4-C-hydroxymethyl group was obtained by an aldol condensation followed by in situ cross Canizzaro reduction. Glycosylation using silylated pyrimidine bases furnished the 2',3'-dideoxy-3',4'- dihydroxymethyl nucleoside analogues.