Synthesis and anti-viral properties of 2',3'-dideoxy-3',4'- dihydroxymethyl substituted pyrimidine nucleoside analogues

Article abstract of DOI:10.1080/15257779508012362

Some 2',3'-dideoxy-3',4'-dihydroxymethyl nucleoside analogues have been synthesised starting from diacetone-D-glucose. The 3-C-hydroxymethyl group was introduced by selective hydroboration-oxidation of the 3-C-methylene derivative. The 4-C-hydroxymethyl group was obtained by an aldol condensation followed by in situ cross Canizzaro reduction. Glycosylation using silylated pyrimidine bases furnished the 2',3'-dideoxy-3',4'- dihydroxymethyl nucleoside analogues.

Full text of DOI:10.1080/15257779508012362

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Synthesis and Anti-viral Properties of
2′,3′-Dideoxy-3′,4′-dihydroxymethyl
Substituted Pyrimidine Nucleoside
Analogues
Magnus Björsne a , Björn Classon a , Inger Kers a , Bertil Samuelsson a
& Ingemar Kvarnström b
a Department of Organic Chemistry, Arrhenius Laboratory ,
Stockholm University , S-106 91, Stockholm, Sweden
b Department of Chemistry , Linköping University , S-431 83,
Linköping, Sweden
Published online: 16 Feb 2007.
To cite this article: Magnus Björsne , Björn Classon , Inger Kers , Bertil Samuelsson & Ingemar
Kvarnström (1995) Synthesis and Anti-viral Properties of 2′,3′-Dideoxy-3′,4′-dihydroxymethyl
Substituted Pyrimidine Nucleoside Analogues, Nucleosides and Nucleotides, 14:3-5, 283-286
To link to this article: http://dx.doi.org/10.1080/15257779508012362
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