1620-14-0

Usage

Chemical Properties

clear yellow to brown liquid

InChI:InChI=1/C7H15NO/c1-4-8(5-2)6-7(3)9/h4-6H2,1-3H3/p+1

Upstream product

• 4079-68-9 N,N-diethyl-2-propynylamine 
• 107-19-7 propargyl alcohol 
• 109-89-7 diethylamine 
• 78-95-5 chloroacetone 
• 598-31-2 1-bromoacetone 
• 13138-17-5 1-Diaethylamino-2,5-dimethyl-2-hydroxy-hexin-⁽³⁾ 
• 2684-62-0 diazoacetone 
• 56-81-5 glycerol 
• 5573-55-7 N,N-diethyl-1,1-dimethyl-1-(prop-1-en-2-yloxy)silanamine 

Downstream Products

• 109-89-7 diethylamine 
• 78-98-8 2-oxopropanal 
• 58124-06-4 1-diethylamino-2-methyl-4-phenyl-butan-2-ol 
• 883-20-5 9-methylphenanthrene 
• 14642-66-1 1-N,N-diethylamino-2-aminopropane 
• 4402-32-8 1-diethylamino-2-propanol 
• 112698-74-5 (E)-1-hydroxy-4-phenylbut-3-en-2-one 
• 58123-87-8 4-Diaethylamino-3-methyl-1-phenyl-butin-⁽¹⁾-ol-⁽³⁾ 
• 108490-28-4 Diethyl-[2-(methyl-diphenyl-silanyl)-2-trimethylsilanyloxy-propyl]-amine 
• 108490-29-5 Diethyl-[2-(methyl-phenyl-p-tolyl-silanyl)-2-trimethylsilanyloxy-propyl]-amine 
• 108490-30-8 [2-(Cyclohexyl-methyl-phenyl-silanyl)-2-trimethylsilanyloxy-propyl]-diethyl-amine 
• 22381-21-1 N,N-diethyl-2-oxo-propanamide 
• 65-85-0 benzoic acid 
• 158697-19-9 1-Diethylamino-2-methyl-4-pentafluorophenyl-but-3-yn-2-ol 

Relevant academic research and scientific papers

Preparation method of N-acetonyl amine compound

The invention discloses a preparation method of an N-acetonyl amine compound. The method comprises the following steps that an amine compound and glycerin are used as reaction raw materials, and in the presence of a composite catalyst and an alkali addition agent, in reaction mediums and at the reaction temperature of 80-180 DEG C, a reaction is performed for 2-48 hours in a sealed reactor so that the N-acetonyl amine compound is obtained. The method disclosed by the invention is simple, reaction conditions are mild, target products can be obtained at a low cost and at a high yield, and the used catalyst has high catalytic activity and is easy to separate and repeatedly use in a reaction system; besides, the whole process is environment-friendly, and the utilization of by-products namely the glycerin of biologic diesel oil is promoted.

Flexible stereoselective functionalizations of ketones through umpolung with hypervalent iodine reagents

The functionalization of carbonyl compounds in the α-position has gathered much attention as a synthetic route because of the wide biological importance of such products. Through polarity reversal, or "umpolung", we show here that typical nucleophiles, such as oxygen, nitrogen, and even carbon nucleophiles, can be used for addition reactions after tethering them to enol ethers. Our findings allow novel retrosynthetic planning and rapid assembly of structures previously accessible only by multistep sequences. A Nu approach: An efficient α-functionalization of ketones with a range of simple and useful nucleophiles is possible by using hypervalent iodine reagents (see scheme; Nu′ can be the Nu itself or a protected form of this nucleophile group).

Asymmetric synthesis of β-dialkylamino alcohols by transfer hydrogenation of α-dialkylamino ketones

Transfer hydrogenation of representative aryl and heteroaryl dialkylaminomethyl ketones with formic acid-triethylamine, catalyzed by RuCl[(R,R)-TsDPEN](η-p-cymene), produces the corresponding β-dialkylamino alcohols, 97-99% ee, in 50-73% yields. Asymmetric synthesis of (R)-macromerine, 98% ee, the cactus Coryphantha macromeris alkaloid, is also described.

Highly chemoselective α-diazo carbonyl insertion reactions into N-H and S-H bonds catalysed by [RuCl(η5-C5H5)(PPh3)2]

Complex [RuCl(η5-C5H5)(PPh3)2], in chloroform at 60 deg C, catalyses the chemoselective insertion of α-diazo carbonyl compounds into N-H and S-H bonds to afford α-keto-amines and α-keto-thioethers.