1620-50-4Relevant academic research and scientific papers
Polymerizable Compositions Based On Thermally Cleavable Compounds
-
Paragraph 0108-0111, (2018/08/03)
The invention relates to a polymerizable composition which comprises a thermolabile polymerizable compound of Formula I: [in-line-formulae]A-[X-(T-X-Sp-X)p-T-X-Q-(Z)n]m?? Formula I,[/in-line-formulae] wherein T represents
New route for the synthesis of N-alkyl-2-(phenylsulfonyl)anilines
Hossan, Aisha
, p. 570 - 573 (2017/03/16)
[Figure not available: see fulltext.] The main objective of this work was to study the rearrangement reactions of 1-alkyl-2-[(phenylsulfonyl)methyl]pyridinium iodides in the presence of various nucleophiles, leading to N-alkyl-2-(phenylsulfonyl)aniline derivatives. The best results were achieved with alkylammonium sulfites, leading to pyridine ring opening followed by recyclization to give diphenyl sulfone derivatives in up to 78% yields.
DENTAL MATERIALS BASED ON MONOMERS HAVING DEBONDING-ON-DEMAND PROPERTIES
-
Paragraph 0210; 0211; 0212; 0213, (2014/11/13)
The invention relates to a dental restorative material which comprises a thermolabile or photolabile polymerizable compound of Formula I: [(Z1)m-Q1-X)]k-T-[Y-Q2-(Z2)n]1??Formula I, in which T represents a thermolabile or photolabile group, Z1 and Z2 in each case independently represent a polymerizable group selected from vinyl groups, CH2═CR1—CO—O— and CH2═CR1—CO—NR2— or an adhesive group selected from —Si(OR)3, —COOH, —O—PO(OH)2, —PO(OH)2, —SO2OH and —SH, wherein at least one Z1 or Z2 is a polymerizable group, Q1 in each case independently is missing or represents an (m+1)-valent linear or branched aliphatic C1-C20 radical which can be interrupted by —O—, —S—, —CO—O—, —O—CO—, —CO—NR3—, —NR3—CO—, —O—CO—NR3—, —NR3—CO—O— or —NR3—CO—NR3—, Q2 in each case independently is missing or represents an (n+1)-valent linear or branched aliphatic C1-C20 radical which can be interrupted by —O—, —S—, —CO—O—, —O—CO—, —CO—NR3—, —NR3—CO—, —O—CO—NR3—, —NR3—CO—O— or —NR3—CO—NR3—, X and Y in each case independently are missing or represent —O—, —S—, CO—O—, —O—CO—, —CO—NR3—, —NR3—CO—, —O—CO—NR3—, —NR3—CO—O— or —NR3—CO—NR3—, R, R1, R2 and R3 in each case independently represent H or a C1-C7 alkyl radical and k, l, m and n in each case independently are 1, 2 or 3.
SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF
-
, (2013/10/22)
The present invention relates to novel substituted methyl-amines, serotonin 5-HT6 receptor antagonists, to active components, pharmaceutical compositions, method for prophylaxis and treatment of CNS diseases and “molecular tools”, in which novel substituted methyl-amines represent compounds of the general formula 1 and their crystalline forms and pharmaceutically acceptable salts, wherein: W represents benzene, naphthalene, indolizine, quinoline or oxazole cycle; R1=H, F, Cl; R2 represents hydrogen, fluoro, methyl, phenyl, thienyl, furan-2-yl, pyridyl, piperazin-1-yl or 4-methylpiperazin-1-yl; R3 represents cyclopropyl or optionally substituted methyl; with the exception of the compounds in which W simultaneously represents oxazole cycle and R2=phenyl or pyridyl.
Rapid bonding/debonding on demand: Reversibly cross-linked functional polymers via diels-alder chemistry
Inglis, Andrew J.,Nebhani, Leena,Altintas, Ozcan,Schmidt, Friedrich Georg,Barner-Kowollik, Christopher
experimental part, p. 5515 - 5520 (2011/10/13)
The synthesis of a novel poly(methyl methacrylate) (PMMA) chain bearing Cp functionality at both chain ends and a trifunctional pyridinyldithioformate linker molecule, which are able to rapidly and reversibly cross-link on demand within a highly accessibl
TETRAHYDROCARBAZOLES AND DERIVATIVES
-
Page/Page column 123, (2010/02/14)
The present invention relates to compounds of the formula (I) wherein R1, R2, R3, R4, R5, X1, X2, X3, X4, n, and k are defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for in the treatment and prophylaxis of diseases which are modulated by LXRα and/or LXR? agonists, including increased lipid and cholesterol levels, particularly low HDL-cholesterol, high LDL-cholesterol, atherosclerotic diseases, diabetes, particularly non-insulin dependent diabetes mellitus, metabolic syndrome, dyslipidemia, Alzheimer's disease, sepsis, inflammatory diseases such as colitis, pancreatitis, cholestasis/fibrosis of the liver, and diseases that have an inflammatory component such as Alzheimer's disease or impaired/improvable cognitive function.
N-sulfonylbenzotriazoles as advantageous reagents for C-sulfonylation
Katritzky, Alan R.,Abdel-Fattah, Ashraf A. A.,Vakulenko, Anatoliy V.,Tao, Hui
, p. 9191 - 9197 (2007/10/03)
Reactions of readily available N-(alkyl-, aryl-, and heteroarylsulfonyl) benzotriazoles 3a-h with diverse nitriles, reactive heteroaromatics, alkylheteroaromatics, sulfones, and esters produced α-cyanoalkyl sulfones 5a-i, sulfonylheteroaromatics 7a-e, α-(sulfonylalkyl)heterocycles 9a-f, α-sulfonylalkyl sulfones 11a-g, and esters of α-sulfonyl acids 14a-c, respectively, in synthetically useful to excellent yields. The results represent the first examples of the successful application of sulfonylazoles for C-sulfonylation.
Efficient new protocol to synthesize aromatic and heteroaromatic dithioesters
Abrunhosa, Isabelle,Gulea, Mihaela,Masson, Serge
, p. 928 - 934 (2007/10/03)
A very efficient, high yielding procedure to synthesize substituted aromatic and heteroaromatic dithioesters is described. It involves the reaction between (phenylsulfonyl)methyl (hetero)aromatic derivatives and elemental sulfur in basic medium, followed by alkylation.
Sulfonic peracids - III. Heteroatom oxidation and chemoselectivity
Kluge,Schulz,Liebsch
, p. 5773 - 5782 (2007/10/03)
We have investigated the p-toluenesulfonic peracid (2) generated in situ in the oxidation of different types of compounds containing nitrogen and/or sulfur. The sulfonic peracid 2 shows a remarkable chemoselectivity characterized by a preferred oxidation of sulfides to the sulfones in the presence of amines or olefins and a strong dependence on the nature of the amine in the competitive oxidation of olefins and amines.
Solvation and metal ion effects on structure and reactivity of phosphoryl compounds. Part 4. Dealkylation of phosphate esters by thiophenoxide ion in methanol
Mentz,Modro,Modro
, p. 1933 - 1960 (2007/10/02)
Second-order rate constants for the demethylation of three phosphate esters by thiophenoxide salts, PhS-M+ (M+ = Me4N+, K+, Na+Li+) in methanol-d4 at 25°C have been measured. In contrast to the demethylation by iodide salts, metallic counterions do not exhibit any catalytic effects on the demethylation rate. The absence of the catalysis indicates that the salts react exclusively as ion pairs, in which an alkali metal ion is not available for the interactions with the phosphoryl group in the transition state.
