71897-63-7

Basic information

• Product Name: 2-((phenylthio)methyl)pyridine
• Synonyms: 2-((phenylthio)methyl)pyridine
• CAS NO: 71897-63-7
• Molecular Formula: C₁₂H₁₁NS
• Molecular Weight: 0
• Mol File: 71897-63-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 324.7°C at 760 mmHg
• Flash Point: 150.2°C
• Appearance: /
• Density: 1.15g/cm³
• Vapor Pressure: 0.000457mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 2-((phenylthio)methyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((phenylthio)methyl)pyridine(71897-63-7)
• EPA Substance Registry System: 2-((phenylthio)methyl)pyridine(71897-63-7)

Safety Data

• Hazardous Substances Data: 71897-63-7(Hazardous Substances Data)

Usage

Structure

A pyridine derivative with a phenylthio group attached to a methyl group.

Usage

In organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active compounds, and as a reagent in chemical reactions (e.g. forming carbon-sulfur bonds).

Potential applications

Development of new drugs and in the field of medicinal chemistry.

Safety precautions

Handle with caution, use in a well-ventilated area, and follow appropriate safety measures due to potential hazardous properties.

InChI:InChI=1/C12H11NS/c1-2-7-12(8-3-1)14-10-11-6-4-5-9-13-11/h1-9H,10H2

Upstream product

• 4377-33-7 2-chloromethylpyridine 
• 108-98-5 thiophenol 
• 100-68-5 methyl-phenyl-thioether 
• 51342-19-9 N-methoxypyridinium methyl sulfate 
• 106966-98-7 potassium 2-(pyridin-2-yl)acetate 
• 882-33-7 diphenyldisulfane 
• 586-98-1 2-Hydroxymethylpyridine 
• 930-69-8 sodium thiophenolate 
• 6959-47-3 2-chloromethylpyridine hydrochloride 
• 109-06-8 α-picoline 
• 2973-86-6 lithium thiophenoxide 
• 99668-67-4 dimethyl (2-pyridylmethyl)phosphate 

Downstream Products

• 1620-50-4 2-<(phenylsulfonyl)methyl>pyridine 
• 99449-44-2 [Pt{2-(phenylthiomethyl)pyridine}Cl₂] 
• 264888-93-9 [PdCl(Me)(C₅H₄N-2-CH₂S(Ph))] 
• 279683-82-8 [Pd(η2-tetramethyl ethylene tetracarboxylate)(C6H5SCH2C5H4N)] 
• 264889-01-2 [Pd(η3-1,1'-dimethylpropadiene)(C5H4N-2-CH2S(Ph))]ClO4 
• 210362-41-7 [Pd(η(3)-C3H5)(2-(phenylthiomethyl)pyridine)]ClO4 
• 279683-68-0 [Pd(η2-1,4-naphthoquinone)(C6H5SCH2C5H4N)] 
• 279683-74-8 [Pd(η2-maleic anhydride)(C6H5SCH2C5H4N)] 
• 279683-88-4 [Pd(η2-tetracyanoethylene)(C6H5SCH2C5H4N)] 
• 705265-90-3 PtClCOCH₃C₅H₄NCH₂SC₆H₅ 
• 863225-59-6 dichloro(2-(phenylthiomethyl)pyridine)palladium 
• 869966-73-4 [(2-(phenylthiomethyl)pyridine)Pd(C₄(CO₂Me)4)] 
• 929874-47-5 [PtBr₄(2-(phenylthiomethyl)pyridine)] 
• 1441253-19-5 [ruthenium(II)(η⁶-benzene)(chloride)(NC5H4CH2SC6H5)](hexafluorophosphate) 

Relevant articles and documents

α-Heteroarylation of Thioethers via Photoredox and Weak Br?nsted Base Catalysis

We report the C-H activation of thioethers to α-thio alkyl radicals and their addition to N-methoxyheteroarenium salts for the redox-neutral synthesis of α-heteroaromatic thioethers. Studies are consistent with a two-step activation mechanism, where oxidation of thioethers to sulfide radical cations by a photoredox catalyst is followed by α-C-H deprotonation by a weak Br?nsted base catalyst to afford α-thio alkyl radicals. Further, N-methoxyheteroarenium salts play additional roles as a source of methoxyl radical that contributes to α-thio alkyl radical generation and a sacrificial oxidant that regenerates the photoredox catalytic cycle.

Regioselective Synthesis of 1-Sulfanyl- and 1-Selanylindolizines

We describe herein a new approach to prepare unprecedented bioactive indolizine motifs decorated with organosulfur and organoselenium groups. A total of 12 1-sulfanylindolizines and 2 1-selanylindolizines were prepared in excellent yields by an intramolecular annulation of easily prepared chalcogen-containing pyridinium salts. The reaction is fast (1 h at 70 °C or 5 min under sonication) and transition-metal-free, using glycerol as a green solvent.

SUBSTITUTED METHYL AMINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS, METHODS FOR PRODUCTION AND USE THEREOF

The present invention relates to novel substituted methyl-amines, serotonin 5-HT6 receptor antagonists, to active components, pharmaceutical compositions, method for prophylaxis and treatment of CNS diseases and “molecular tools”, in which novel substituted methyl-amines represent compounds of the general formula 1 and their crystalline forms and pharmaceutically acceptable salts, wherein: W represents benzene, naphthalene, indolizine, quinoline or oxazole cycle; R1=H, F, Cl; R2 represents hydrogen, fluoro, methyl, phenyl, thienyl, furan-2-yl, pyridyl, piperazin-1-yl or 4-methylpiperazin-1-yl; R3 represents cyclopropyl or optionally substituted methyl; with the exception of the compounds in which W simultaneously represents oxazole cycle and R2=phenyl or pyridyl.