1620141-91-4Relevant academic research and scientific papers
Total synthesis of fluoxetine and duloxetine through an in situ imine formation/borylation/transimination and reduction approach
Calow, Adam D. J.,Fernandez, Elena,Whiting, Andrew
, p. 6121 - 6127 (2014)
We report efficient, catalytic, asymmetric total syntheses of both (R)-fluoxetine and (S)-duloxetine from α,β-unsaturated aldehydes conducting five sequential one-pot steps (imine formation/copper mediated β-borylation/transimination/reduction/oxidation) followed by the specific ether group formation which deliver the desired products (R)-fluoxetine in 45% yield (96% ee) and (S)-duloxetine in 47% yield (94% ee). This journal is the Partner Organisations 2014.
