16205-32-6

Basic information

• Product Name: 2-fluoroestradiol
• Synonyms: Estra-1,3,5(10)-triene-3,17b-diol, 2-fluoro- (8CI);2-Fluoro-17b-estradiol; 2-Fluoroestradiol;NSC 97849
• CAS NO: 16205-32-6
• Molecular Formula: C18H23 F O2
• Molecular Weight: 290.37
• Mol File: 16205-32-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 177 °C
• Boiling Point: 421.8°Cat760mmHg
• Flash Point: 208.9°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 7.23E-08mmHg at 25°C
• Refractive Index: 1.586
• PKA: 9.03±0.60(Predicted)
• CAS DataBase Reference: 2-fluoroestradiol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoroestradiol(16205-32-6)
• EPA Substance Registry System: 2-fluoroestradiol(16205-32-6)

Safety Data

• Hazardous Substances Data: 16205-32-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H23FO2/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-16(20)15(19)9-13(10)11/h8-9,11-12,14,17,20-21H,2-7H2,1H3

Upstream product

• 1881-35-2 2-fluorooestrone 
• 125363-77-1 (2R,4R,5R,8R,9S,10R,13S,14S,17S)-2-Fluoro-17-hydroxy-13-methyl-tetradecahydro-20-oxa-cyclopropa[4,5]cyclopenta[a]phenanthren-3-one 
• 50-28-2 estradiol 
• 434-22-0 19-nortestosterone 
• 1035-77-4 3-O-methyl-17β-oestradiol 
• 16205-34-8 2-fluoro-17β-estradiol diacetate 
• 85382-37-2 3,17β-bis(trimethylsilyloxy)-4,5β-epoxyestr-2-ene 
• 3941-50-2 (4R,5R,8R,9S,10R,13S,14S,17S)-17-Hydroxy-13-methyl-tetradecahydro-20-oxa-cyclopropa[4,5]cyclopenta[a]phenanthren-3-one 
• 1093411-48-3 estradiol 

Downstream Products

• 362-05-0 2-Hydroxyestradiol 

Related news

Effects of 2-fluoroestradiol (cas 16205-32-6) on lipid metabolism in the ovariectomized rat07/25/2019

Biological activities of estrogen molecules are altered by fluorination of ring A, and the resulting impairment to form catechols. 2-fluoroestradiol (2-F-E2) has been found to be devoid of carcinogenic action despite its high estrogenic potency; its metabolic effects are so far unknown. This stu...detailed

Novel synthesis of 2-fluoroestradiol (cas 16205-32-6) from 19-Cortestosterone: Biomimetic oxidative defluorination to 2-hydroxyestradiol07/24/2019

A new, short synthetic route to 2-fluoroestradiol from 19-nortestosterone is described which gives the target compound in an approximately 25% overall yield. Oxidative defluorination of 2-fluoroestradiol to 2-hydroxyestradiol via treatment with Frémy's salt/iodide ion is reported. This pro...detailed

Relevant articles and documents

Novel synthesis of 2-fluoroestradiol from 19-nortestosterone: Biomimetic oxidative defluorination to 2-hydroxyestradiol

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Fluorination of steroid estrogens with Selectfluor??: Elucidation of regio- and stereoselectivity

Two steroid estrogens, natural estradiol and 8?±-estradiol, were fluorinated using Selectfluor?? in ionic liquid. Unexpectedly, mostly products of fluorination at position C-10 were isolated instead of corresponding fluorophenols, as it was reported previ

Efficient regioselective a-ring functionalization of oestrogens

Complete series of 2-halo- and 2-cyano-oestrogens have been prepared in good to high yields: 2-chloro, 2-bromo, 2-iodo, and 2-cyano derivatives via oestrogen-thallium (III) bis(trifluoroacetate) intermediates, and 2- and 4- fluorooestrogens by direct functionalization using N-fluoropyridinium triflate.