Novel synthesis of 2-fluoroestradiol (cas 16205-32-6) from 19-Cortestosterone: Biomimetic oxidative defluorination to 2-hydroxyestradiol

Add time:07/24/2019    Source:sciencedirect.com

A new, short synthetic route to 2-fluoroestradiol (cas 16205-32-6) from 19-nortestosterone is described which gives the target compound in an approximately 25% overall yield. Oxidative defluorination of 2-fluoroestradiol to 2-hydroxyestradiol via treatment with Frémy's salt/iodide ion is reported. This process is regarded as biomimetic with respect to cytochrome P-450-dependent oxidative defluorination.

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