1620752-75-1Relevant academic research and scientific papers
An integration of condensation/Ullmann-type coupling/bicyclization sequences: Copper-catalyzed three-component direct synthesis of [1,2,4]triazolo[1,5-b]isoquinolin-5(1H)-ones
Jia, Feng-Cheng,Xu, Cheng,Cai, Qun,Wu, An-Xin
supporting information, p. 9914 - 9916 (2014/08/18)
A highly efficient three-component domino protocol has been developed for the synthesis of [1,2,4]triazolo[1,5-b]isoquinolin-5(1H)-ones from simple and readily available o-halogenated benzohydrazides, aldehydes and nitriles. This domino process involves sequential selective condensation, copper-catalyzed intermolecular C-arylation and bicyclization. Notably, the use of ligands and anaerobic conditions can be avoided in this reaction.
