1622096-30-3

Upstream product

• 164021-78-7 (1S,2R)-3-(2-bromoethyl)cyclohex-5-ene-1,2-diol 
• 1315613-95-6 2-(2,2-dimethyl-3a,6,7,7a-tetrahydrobenzo[d][1,3]dioxol-4-yl)-N-methylethanamine 
• 1315613-94-5 C₁₁H₁₇BrO₂ 
• 164021-77-6 (5S,6R)-1-(2-bromoethyl)cyclohexa-1,3-dien-5,6-diol 
• 103-63-9 1-phenyl-2-bromoethane 
• 65299-00-5 3-hydroxy-4-(methoxymethoxy)benzaldehyde 
• 65298-99-9 acetic acid 5-formyl-2-hydroxy-phenyl ester 
• 65298-95-5 3-Acetoxy-4-(methoxymethoxy)benzaldehyd 
• 139-85-5 3,4-dihydroxybenzaldehyde 

Downstream Products

• 1622096-24-5 tert-butyl (2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(2-(methoxy-methoxy)-5-vinylphenoxy)cyclohex-1-en-1-yl)ethyl)(methyl)carbamate 
• 1622096-25-6 tert-butyl (2-((5S,6S)-5-((tert-butyldimethylsilyl)oxy)-6-(2-hydroxy-5-vinylphenoxy)cyclohex-1-en-1-yl)ethyl)(methyl)carbamate 
• 1622096-26-7 (4aS,4a1R,5S,7aR)-5-((tert-butyldimethylsilyl)oxy)-4a1-(2-(N,4-dimethylphenylsulfonamido)ethyl)-4a,4a1,5,6,7,7a-hexahydro phenanthro[4,5-bcd]furan-3-yl 4-methylbenzenesulfonate 

Relevant academic research and scientific papers

PROCESS FOR PREPARING MORPHINE COMPOUNDS

The present application relates to processes for the preparation of morphine compounds utilizing a novel intramolecular [4+2] cycloaddition reaction.

Short chemoenzymatic total synthesis of ent-hydromorphone: An oxidative dearomatization/intramolecular [4+2] cycloaddition/amination sequence

A short synthesis of ent-hydromorphone has been achieved in twelve steps from β-bromoethylbenzene. The key transformations involved the enzymatic dihydroxylation of the arene to the corresponding cis-dihydrodiol, Mitsunobu coupling with the ring?A fragmen