162218-92-0

Basic information

• Product Name: 5-Isoxazolecarboxylicacid,4,5-dihydro-3-(1-methylethyl)-,methylester(9CI)
• Synonyms: 5-Isoxazolecarboxylicacid,4,5-dihydro-3-(1-methylethyl)-,methylester(9CI)
• CAS NO: 162218-92-0
• Molecular Formula: C8H13NO3
• Molecular Weight: 171.19
• Product Categories: ISOPROPYL
• Mol File: 162218-92-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Isoxazolecarboxylicacid,4,5-dihydro-3-(1-methylethyl)-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Isoxazolecarboxylicacid,4,5-dihydro-3-(1-methylethyl)-,methylester(9CI)(162218-92-0)
• EPA Substance Registry System: 5-Isoxazolecarboxylicacid,4,5-dihydro-3-(1-methylethyl)-,methylester(9CI)(162218-92-0)

Safety Data

• Hazardous Substances Data: 162218-92-0(Hazardous Substances Data)

Upstream product

• 200352-43-8 3-Isopropyl-2-(4-methoxy-benzyl)-isoxazolidine-5-carboxylic acid methyl ester 
• 5775-73-5 (1E)-2-methylpropanal oxime 
• 292638-85-8 acrylic acid methyl ester 
• 151-00-8 isobutyraldehyde oxime 

Relevant articles and documents

BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF

The invention provides novel compounds having the general formula (I): (I) wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.

In Situ Generation of Nitrile Oxides from NaCl-Oxone Oxidation of Various Aldoximes and Their 1,3-Dipolar Cycloaddition

Reported is a new green protocol for the efficient in situ generation of nitrile oxides through NaCl/Oxone oxidation of aldoximes and their dipolar cycloaddition. The key feature is the use of a green chemistry approach to address the substrate scope of aldoximes: broad scope (aliphatic, aromatic, and alkenyl aldoximes) without production of organic byproducts derived from oxidant and/or catalyst. Importantly, NaCl/Oxone-promoted three-component cycloaddition of aldehyde, hydroxylamine hydrochloride, and alkene was demonstrated to be competent (63-81%).