162269-91-2Relevant articles and documents
A concise synthetic approach to dihydrochalcone: First total syntheses of bipinnatone A and B
Zhao, Xiao Long,Li, Hui Zhi,Zhang, Xian Shu,Wang, Wen Jing,Da, Shi Jun,Li, Ying
scheme or table, p. 1135 - 1138 (2012/01/06)
The first total syntheses of bipinnatone A and B have been achieved starting from commercially available phloroglucinol, p-hydroxybenzaldehyde in ten steps. Key features of the syntheses include Aldol reaction, aryl-alkylation and InCl3-NaBH4 selective reduction.
Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan
Esumi, Tomoyuki,Makado, Gouki,Zhai, Haifeng,Shimizu, Yasuhiro,Mitsumoto, Yasuhide,Fukuyama, Yoshiyasu
, p. 2621 - 2625 (2007/10/03)
Honokiol, a biphenyl-type neolignan, which shows the remarkable neurotrophic effect in primary cultured rat cortical neurons, has been effectively synthesized in 21% yield over 14 steps starting from 5-bromosalicylic acid and p-hydroxybenzoic acid by utilizing Pd-catalyzed Suzuki-Miyaura coupling reaction as a key step. Additionally, the structure-activity relationship between neurite outgrowth-promoting activity and its O-methylated and/or its hydrogenated analogues was examined in the primary cultures of fetal rat cortical neurons, suggesting that 5-allyl and 4′-hydroxyl groups are essential for affecting the neurotrophic activity of honokiol.
Short and efficient synthesis of (+)-subersic acids
Basabe, Pilar,Diego, Alberto,Delgado, Sergio,Díez, David,Marcos, Isidro S.,Urones, Julio G.
, p. 9173 - 9177 (2007/10/03)
An efficient synthesis of (+)-subersic acid, the unnatural enantiomer, has been achieved from sclareol and p-hydroxybenzoic acid.
