16237-19-7

Upstream product

• 2051-76-5 acrylic acid anhydride 
• 41609-04-5 N-benzyl-3-amino-2-cyclohexen-1-one 
• 814-68-6 acryloyl chloride 
• 386767-67-5 1-(2-bromo-benzyl)-4,6,7,8-tetrahydro-1H,3H-quinoline-2,5-dione 
• 3959-05-5 2-bromobenzylamine 
• 504-02-9 1,3-cylohexanedione 
• 386767-62-0 3-(2-bromo-benzylamino)-cyclohex-2-enone 
• 100-46-9 benzylamine 
• 5057-12-5 3,4,7,8-tetrahydro-2,5(1H,6H)-quinolinequinone 
• 100-39-0 benzyl bromide 

Downstream Products

• 154309-15-6 1-Benzyl-5-hydroxy-octahydro-quinolin-2-one 
• 27766-71-8 (+/-)-5-epipumiliotoxin C 

Relevant academic research and scientific papers

A straightforward approach to the galanthan ring system using the imine Michael reaction followed by a radical cyclization

A two-step procedure based on the Michael reaction of imines followed by a radical cyclization has proved to be a regioselective and stereoselective method for the construction of the skeleton of galanthan-type alkaloids.

'Decahydroquinoline construction through aza-annulation: A stereoselective synthesis of (±)-5-epipumiliotoxin C.'

Aza-annulation of activated acrylic acid derivatives with 3-benzylamino-2-cyclohexenone led to the efficient formation of the corresponding bicyclic lactam. Stereospecific hydrogenation of this unsaturated lactam resulted in the selective formation of the cis fused bicyclic alkaloid, and subsequent elaboration at C-5 and C-2 completed the synthesis of the decahydroquinoline alkaloid (±)-5-epipumiliotoxin C.

Pharmaceutical compositions containing quinolin-2,5-diones, new quinolin-2,5-diones and processes for the preparation thereof

This invention relates to pharmaceutical compositions containing quinolin-2,5-diones of formula STR1 wherein A, B, R1 to R3 and X are defined hereinbelow, some of which are novel, which compounds have valuable pharmacological propert