162426-75-7

Usage

Uses

Used in Pharmaceutical Industry:
[1,1'-Binaphthalen]-2-ol, 2'-(diphenylphosphinyl)is used as a chiral ligand for the development of new pharmaceuticals. Its ability to induce chirality in metal complexes makes it a valuable tool in the synthesis of enantiomerically pure drugs, which are essential for the treatment of various medical conditions.
Used in Chemical Industry:
In the chemical industry, [1,1'-Binaphthalen]-2-ol, 2'-(diphenylphosphinyl)is used as a catalyst in asymmetric synthesis. Its enantioselective properties enable the production of chiral compounds with high purity, which are crucial for the development of new materials and chemicals with specific applications.
Used in Research and Development:
[1,1'-Binaphthalen]-2-ol, 2'-(diphenylphosphinyl)is also utilized in research and development for the exploration of new synthetic methodologies and the study of chiral chemistry. Its unique properties make it an essential compound for advancing the understanding of enantioselective reactions and the development of novel catalysts and ligands.

Upstream product

• 194-63-8 dinaphtho[2,1-b;1',2'-d]furan 
• 1499-21-4 Diphenylphosphinic chloride 
• 132532-07-1 [1,1'-binaphthalen]-2-yldiphenylphosphine oxide 
• 90948-03-1 1-bromo-2-iodonaphthalene 
• 1589518-11-5 (1-bromonaphthalen-2-yl)diphenylphosphine oxide 
• 4559-70-0 Diphenylphosphine oxide 
• 141807-44-5 (+/-)-2,2'-bis(trifluoromethanesulfonyloxy)-1,1-binaphthyl 
• 602-09-5 1,1'-bi-2-naphthol 
• 199681-29-3 Diphenyl-(2'-trimethylsilanyloxy-[1,1']binaphthalenyl-2-yl)-phosphane 
• 149917-88-4 (S)-(-)-2-hydroxy-2'-diphenylphosphino-1,1'-binaphthyl 
• 132532-04-8 (R)-2-diphenylphosphinyl-2'-trifluoromethanesulfonyloxy-1,1'-binaphthalene 

Downstream Products

• 149917-88-4 (S)-(-)-2-hydroxy-2'-diphenylphosphino-1,1'-binaphthyl 
• 194-65-0 1,1'-binaphthothiophene 
• 162305-89-7 (R,S)-2-(diphenylphosphanyl)-1,1'-binaphthyl-2'-thiol 
• 162426-77-9 2-(diphenylphosphinyl)-1,1'-binaphthyl-2'-thiol-N,N-dimethylcarbamate 
• 374687-37-3 2-(diphenylphosphanyl)-1,1'-binaphthyl-2'-thiol-N,N-dimethylcarbamate 
• 186083-75-0 dichlorobis[(S)-2-diphenylphosphinoyl-1,1'-binaphthalene-2'-olato]titanium(IV) 
• 137769-32-5 (S)-(-)-2-(diphenylphosphino)-2'-ethyl-1,1'-binaphthyl 
• 137769-31-4 (S)-(-)-2-(diphenylphosphino)-2'-(benzyloxy)-1,1'-binaphthyl 
• 137769-30-3 (S)-(-)-2-(diphenylphosphino)-2'-(isopropoxy)-1,1'-binaphthyl 
• 161053-46-9 (S)-(-)-2-methoxy-2'-diphenylphosphino-1,1'-binaphthyl 
• 205238-71-7 (R)-2'-diphenylphosphino-6-vibyl-1,1'-binaphthalen-2-yl (S)-1,1'-binaphthalene-2,2'-diyl phosphite 
• 213314-18-2 (R)-6-vinyl-2'-diphenylphosphino-2-hydroxy-1,1'-binaphthalene 
• 213314-17-1 2'-diphenylphosphino-2-hydroxy-6-bromo-1,1'-binaphthalene 

Relevant academic research and scientific papers

Axially Chiral Biaryl Monophosphine Oxides Enabled by Palladium/WJ-Phos-Catalyzed Asymmetric Suzuki-Miyaura Cross-coupling

A highly enantioselective palladium/WJ-Phos-catalyzed Suzuki-Miyaura coupling reaction for efficient construction of axially chiral biaryl monophosphine oxides was developed. A series of axially chiral biaryl monophosphine oxides were obtained in good yields and with high enantioselectivities. The practicability of this reaction was validated in the straightforward synthesis of axially chiral biaryl monophosphine ligand and demonstrated by a 100-g-scale synthesis. Moreover, various functionalizations of the product make it as a platform molecule for synthesis of other chiral biaryl phosphines.

Pd(II)-catalyzed C(sp2)-H hydroxylation with R 2(O)P-coordinating group

A novel R2(O)P-directed Pd(II)-catalyzed C-H hydroxylation to synthesize various substituted 2′-phosphorylbiphenyl-2-ol compounds is described. Notably, the reaction operates under mild conditions and shows good functional group tolerance, high selectivity, and yield.

A concise synthesis of 2-diarylphosphino-2′-methoxy-1,1′- binaphthalenes (MOPs) by simple resolution

A practical synthesis of 2-diarylphosphino-2′-methoxy-1,1′- binaphthalene (MOPs) was provided by employing the etherification of 1,1′-bi-2,2′-naphthol on zeolite; the ring opening of the ether with lithium; the reaction with chlorodiaryl phosphine and the

Optically active phosphine derivative having at least two vinyl groups, polymer produced using the same as monomer, and transition metal complexes of these

A 2′-diarylphosphino-1,1′-biphenylen-2-yloxy(6,6′-divinyl-1,1′-binaphthalene-2,2′-diyloxy)phosphine derivative is disclosed, which is represented by general formula (I): wherein Ar is an optionally substituted phenyl or naphthyl; R1and R2

Optically active phosphine derivative having vinyl group, polymer produced using the same as monomer, and transition metal complexes of these

A 6-vinyl-2'-diarylphosphino-1,1'-binaphthalen-2-yloxy(biphenylene-2,2'-diyloxy)phosphine derivative is disclosed, which is represented by general formula (I): wherein Ar is an optionally substituted phenyl or naphthyl; R1 and R2 each independently is a h

Phosphine derivative and polymer thereof and transition metal complex comprising the same

Disclosed are a phosphine derivative represented by formula (I): wherein Ar represents a substituted or unsubstituted phenyl group or a substituted or unsubstituted naphthyl group, a transition metal complex comprising the phosphine derivative or a polyme

P/O ligand systems: Facile synthesis, structure, and catalytic tests of 2′-phosphanyl-1,1′-bipheny 1-2-ols and 2′-phosphanyl-1,1′-binaphthyl-2-ols

A facile synthesis of 2′-phosphanyl-1,1′-biphenyl- and 2′-phosphanyl-l,1′-binaphthyl-2-ols and their silyl ethers has been developed, consisting of electron-transfer-catalyzed ring-opening of dibenzofuran and dinaphthofuran, respectively, subsequent reaction with chlorophosphanes, and work-up with acetic acid or ClSiMe3. Studies of the molecular and crystal structures reveal the presence of P...H-O bridging bonds in the more basic /BuPhP derivative and a nearly perpendicular arrangement of the aryl planes in the biphenyl derivatives. The barrier to rotation of the aryl planes about the C-C axis was determined by NMR in the case of the P-asymmetric derivative 3d, using the appearance of diastereoisomers by atropisomerism and P-asymmetry. Comparative screening tests of the title compounds, phosphanylphenols and phosphanylnaphthols in homogeneous Rh-catalyzed reactions demonstrate catalytic activity in hydroformylation reactions and superior properties of the biphenyl- and binaphthyl-2-ol derivatives in relation to other P-O ligands. WILEY-VCH Verlag GmbH, 1997.

Novel Heterobidentate Ligands for Asymmetric Catalysis: Synthesis and Rhodium-catalysed Reactions of S-Alkyl (R)-2-Diphenylphosphino-1,1'-binaphthyl-2'-thiol

Atropisomerically pure S-alkyl (R)-2-diphenylphosphino-1,1'-binaphthyl-2'-thiol derivatives have been synthesized through a multistep reaction sequence starting from (R)-binaphthol.Pd(II) and Rh(II) complexes containing the S-methyl derivative 14 as a chelate ligand have been prepared and characterized.Rh(I) complexes containing 14 or the S-iso-propyl derivative 15 effectively catalyse the asymmetric hydroformylation of styrene and the hydrogen transfer reduction of acetophenone.