Stereoselective Synthesis of 9β-Hydroxytaxanes via Reduction with Samarium Diiodide

Article abstract of DOI:10.1016/0040-4039(95)00142-Y

Reaction of baccatin III and paclitaxel with samarium diiodide yielded the corresponding 10-deacetyl-9β-hydroxy derivatives.When 10-deacetylbaccatin III and docetaxel were subjected to the same reaction conditions the corresponding 9β-hydroxy and 10-dehyd