162536-47-2

Upstream product

• 1120-87-2 4-bromopyridin 
• 108957-20-6 (R)-N-(tert-butoxycarbonyl)-3-iodoalanine benzyl ester 
• 94882-74-3 benzyl 2(S)-(tert-butoxycarbonylamino)-3-p-toluenesulfonylpropionate 
• 59524-02-6 N-tert-butoxycarbonyl-L-serine benzyl ester 
• 100-39-0 benzyl bromide 
• 37535-57-2 (S)-2-((tert-butoxycarbonyl)amino)-3-(pyridin-4-yl)propanoic acid 

Downstream Products

• 218444-63-4 (S)-2-tert-Butoxycarbonylamino-3-(1-oxy-pyridin-4-yl)-propionic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis of all Three Regioisomers of Pyridylalanine

Pyridylalanines 4-6, differing from one another by the position of attachment on the heterocyclic ring were synthesized in moderate yield starting from serine and 2-, 3- and 4-bromopyridine respectively.

Design and synthesis of a pyridone-based phosphotyrosine mimetic

A novel pyridone-based tyrosine analog, 6, has been designed to mimic the binding interaction of SH2 domains with phosphotyrosine (pTyr) containing peptides. Synthesis of 6 features a key Pd catalyzed coupling of β- iodoalanine with phosphonomethyl 4-pyridone triflate.