218444-63-4Relevant academic research and scientific papers
Design and synthesis of a pyridone-based phosphotyrosine mimetic
Fu, Jian-Min,Castelhano, Arlindo L.
, p. 2813 - 2816 (1998)
A novel pyridone-based tyrosine analog, 6, has been designed to mimic the binding interaction of SH2 domains with phosphotyrosine (pTyr) containing peptides. Synthesis of 6 features a key Pd catalyzed coupling of β- iodoalanine with phosphonomethyl 4-pyridone triflate.
